MDSC 515 Questions and Answers | New One | Grade A+

biomarkers Ans: -objective and quantifiable measurement or characteristic of a biological process -indicator of a biologic process -molecular pathology = gene or gene product associated with a disease process ideal biomarker Ans: -relevant and valid to a specific disease state -provides actionable or prognostic info -quantifiable in easily obtained tissue or fluid -economical to test in a reproducible fashion caveat to biomarkers Ans: -molecular pathology biomarkers can be the protein, specific mutation, copy number alteration or the fusion gene product -specific biomarker can be associated with multiple diseases and have multiple types of alteration, each with different disease associations types of biomarkers Ans: -predisposition -diagnostic -prognostic -predictive predisposition biomarkers Ans: -indicates a risk or likelihood that a disease process will occur prior to symptoms -prenatal screening for inherited syndromes diagnostic biomarkers Ans: -pathognomonic = defines/diagnoses the specific entity - characteristic or indicative of disease -typically the status of the biomarker is included in the diagnostic criteria for the disease in question -CFTR mutations are required for cystic fibrosis to develop -some biomarkers are diagnostic of multiple diseases or some are diagnostic in one and not another even if its present prognostic biomarker