Pharmacokinetics Exam 1 Elaboration set complete with Answers.

Pharmacokinetics Exam 1 Elaboration set complete with Answers. 4 main classifications of protein synthesis inhibitors - Correct Answer 1. tetracyclines 2. glycylcyclines 3. aminoglycosides 4. macrolides/ketolides transport protein in bacterial cells that expel toxic substances - Correct Answer efflux pump tetracyclines bactericidal or bacteriostatic? - Correct Answer bacteriostatic tetracycline MOA - Correct Answer bind 30S ribosomal subunit, distorts it such that tRNAs can't line up with mRNA and protein translation is blocked 3 MORs against tetracyclines - Correct Answer 1. efflux pumps expel drug from inside cell 2. bacterial enzymes inactivate the drug 3. bacterial proteins can prevent tetracyclines from ribosomal binding Are the MORs "all for one" regarding tetracyclines? - Correct Answer No, not all for one. A bacterium could be resistant to tetracycline but not doxycycline. tetracycline spectrum? bacteria types (like gram+/-) TCN is active against? - Correct Answer Broad spectrum, active against gram+, gram-, and "other organisms" Mnemonic for agents tetracycline treats? - Correct Answer Love My Chronic CRAP What does tetracycline treat? - Correct Answer Lyme disease Mycoplasma pneumonia (walking pneumonia) Cholera Chlamydia Rocky mountain spotted fever Acne Peptic ulcers casued by H. pylori 4 tetracycline drugs - Correct Answer demeclocycline doxycycline minocycline tetracycline route of administration for tetracyclines - Correct Answer oral what foods should you avoid when taking tetracyclines? why? – Correct Answer -dairy, antacids, iron supplements within 2-3 hours -because these products bind tetracycline and prevent its absorption