PHA 428: Exam 1 AVW Exam Questions with Correct Answers

What meds are included in polyene macrocodes? Correct Answer -Amphotericin B -Nystatin What is the MOA of polyene macrolides? Correct Answer -binds to ergosterol (membrane lipid) -creates pores in the membrane -cell contents leak out Describe amphotericin B in renal impairment Correct Answer ACUTE PHASE -vasoconstriction of renal afferent arteriole -low glomerular blood pressure -low filtration CHRONIC USE -damage to tubular cells -potassium and magnesium wasting What is the MOA of azole antifungals? Correct Answer -inhibit ergosterol synthesis -blocks lanosterol early on -CYP 450 interaction Which azole antifungals have lower risk of interactions? Correct Answer -triazoles Describe azole elimination Correct Answer -most hepatically eliminated -fluconazole is RENALLY eliminated What meds are in echinocandins? Correct Answer -echinocandin -caspofungin -micafungin -anidulafungin What is the MOA of echinocandins? Correct Answer -Blocks B-glucan synthase -Blocks critical sugar synthesis in cell wall What meds are in squalene epoxidase inhibitors? Correct Answer -terbinafine -naftifine -tolnaftate What is the MOA of squalene epoxidase inhibitors? Correct Answer -inhibit ergosterol biosynthesis -block squalene epoxidase What is the MOA of griseofulvin? Correct Answer -inhibits microtubule function -disrupts fungal cell division What is the MOA of flucytosine? Correct Answer -converted to FdUMP