Pharmacology: Pharmacokinetics Exam Questions with 100% Correct Answers

After administrations, what are the 4 Pharmacokinetic Properties? Correct Answer -Absorption -Distribution -Metabolism -Excretion What do the 4 pharmacokinetic properties determine? Correct Answer -the speed of onset of drug action -the intensity of the drug's effect -its duration of action What does knowledge of pharmacokinetic parameters allow? Correct Answer The pharmacist to optimize and design treatment regimens (including decision about the route of administration ad the dosage) What barriers must a drug cross in order to have access to its site of action? Correct Answer A drug must cross PHYSICAL, CHEMICAL, and BIOLOGICAL barriers What are the characteristics of drugs that affect their movement and availability at sites of action? Correct Answer - Molecular size - Structural features - Degree of ionization - Relative lipid solubility of its ionized and nonionized forms - Binding to plasma and tissue proteins (including fat) What is the common barrier to drug transport? Correct Answer The plasma membrane What are the basic mechanisms involved in drug transport across plasma membranes? Correct Answer - Plasma diffusion - Facilitated diffusion - Active transport - Endocytosis What dominates transmembrane movement of most drugs? Correct Answer Passive Diffusion Passive Diffusion consists of what three processes? Correct Answer 1) Partition from the aqueous to the lipid phase 2) Diffusion across the lipid bilayer 3) Repartition into the aqueous phase Diffusion that occurs down an electrochemical or concentration gradient of the drug? Correct Answer Passive Diffusion