LEHNE’S PHARMACOTHERAPEUTICS FOR ADVANCED PRACTICE NURSES AND PHYSICIAN ASSISTANTS TEST BANK WITH CORRECT ANSWERS

LEHNE’S PHARMACOTHERAPEUTICS FOR ADVANCED PRACTICE NURSES AND PHYSICIAN ASSISTANTS TEST BANK WITH CORRECT ANSWERS A nurse is teaching a group of students about how CNS drugs are developed. Which statement by a student indicates a need for further teaching? a. "Central nervous system drug development relies on observations of their effects on human behavior." b. "Studies of new central nervous system drugs in healthy subjects can produce paradoxical effects." c. "Our knowledge of the neurochemical and physiologic changes that underlie mental illness is incomplete." d. "These drugs are developed based on scientific knowledge of CNS transmitters and receptors." - -answer-ANS: D The deficiencies in knowledge about how CNS transmitters and receptors work make systematic development of CNS drugs difficult. Testing in healthy subjects often leads either to no effect or to paradoxical effects. Medical knowledge of the neurochemical and physiologic changes underlying mental illness is incomplete. The development of CNS drugs depends less on knowledge of how the CNS functions and how these drugs affect that process and more on how administering one of these agents leads to changes in behavior. A nurse is teaching a group of nursing students how the CNS adapts to psychotherapeutic medications. Which statement by a nursing student indicates a need for further teaching? a. "Adaptation can lead to tolerance of these drugs with prolonged use." b. "Adaptation helps explain how physical dependence occurs." c. "Adaptation often must occur before therapeutic effects develop." d. "Adaptation results in an increased sensitivity to side effects over time." - - answer-ANS: D With adaptation of the central nervous system to prolonged exposure to CNS drugs, many adverse effects diminish and therapeutic effects remain. Adaptation helps explain how tolerance and physical dependence occur, as the brain adapts to the p