Summary Non-steroidal anti-inflammatory drugs explained

STEP-UP therapy TOP-DOWN therapy

1. 5-ASA/SPS 1. Anti-TNF
2. Steroids 2. AZA-MTX
3. AZA/MTX 3. Combination
4. Anti-TNF 4. Steroids



IBD drugs

Aminosalicylates  Sulfasalazine
 5-ASAs
 Mesalamine
 Balsalazide
 Olsalazine
Immunomodulators  Azathioprine
 6-mercaptopurine
 Methotrexate
 Cyclosporine
 Tacrolimus
TNF alpha inhibitors  Infliximab
 Adalimumab
 Golimumab
 Certolizumab
 Natalizumab
 Ustekinumab
Others
Antibiotics  Metronidazole
 Ciprofloxacin
Steroids  Prednisone
 Budesonide
 Hydrocortisone
 Topical foam
 Enema
 Suppositories