Antidiabetic Medications Overview Exam Review Solution

Antidiabetic Medications Overview Exam Review Solution Xanthine Oxidase Inhibitors - ANS-Medications like colchicine, allopurinol, and febuxostat used to treat gout Colchicine Dosing - ANS-Initial dose of 1.2 mg at first sign of flare, then 0.6 mg 1 hour later (MAX: 1.8 mg/hour) Colchicine Side Effects - ANS-Diarrhea, malabsorption of B12, hepatotoxicity, renal stone development, myopathy, neuropathy Allopurinol Usage - ANS-Prophylactic treatment of gout, not for acute flares Steroids Mechanism - ANS-Inhibits arachidonic acid metabolism, stabilizes biologic membranes, impairs phagocytosis, lymphocytes, and tissue repair Steroids GI Side Effects - ANS-GI bleeding, peptic ulcer disease, ulcerative colitis, nephrotic syndrome, hepatic disease Steroids Skin Side Effects - ANS-Thinning of skin, alopecia, acne, purpura, striae, hirsutism, muscle wasting Steroids Skeletal Side Effects - ANS-Osteoporosis, skeletal fractures; treated with alendronate or risedronate Steroids Ocular Side Effects - ANS-Subcapsular cataracts, glaucoma, optic nerve damage NSAIDs Black Box Warning - ANS-