Advanced Patho NURS 5315 exam 1

Advanced Patho NURS 5315 exam 1 action potential The process by which excitable cells transmit information from one to another. How is the action potential altered by a potassium imbalance? (Hyperkalemia) The ECF has more K+ ions. The membrane potential becomes more positive (hypopolarized). Cells become MORE excitable. T waves peak. QRS complexes widen. Causes dysrhythmias, weakness, paresthesia. {If membrane potential becomes equal to threshold potential cardiac standstill occurs} How is the action potential altered by a potassium imbalance? (Hypokalemia) The ECF has less K+ ions. The membrane potential becomes more negative or hyper-polarized. The cell becomes less excitable, depolarization takes longer, and takes a stronger stimulus. Causes weakness, atony, cardiac dystrhythmias. How is the action potential altered by a calcium imbalance? (hypercalemia) Increase in ECF calcium to 10.5 mg/dL. It decreases the cell permeability to calcium. The cell becomes hyperpolarized (the distance between membrane potential and threshold potential widens). The cell is less excitable and take more stimulus to depolarize. Causes: weakness, hyporeflexia, lethargy, confusion, shortened QT wave, depressed T wave. How is the action potential altered by a calcium imbalance? (hypocalemia) Decreased ECF calcium 9.0 mg/dL. 5.5 ionized. Increases the cell permeability to Na+. Resting membrane potential gets hypo-polarized. Cells become excitable and threshold and membrane potential get closer. Causes: tetany, hyperreflexia, parathesias, seizures, dysrhythmias. Atrophy Catabolism of intracellular organelles causing a reduction in the intracellular contents. The cell shrinks -The thymus gland shrinks in childhood -Disuse atrophy hypertrophy Hormonal stimulation in response to increased demand than causes an increase in cellular protien. The cell gets larger - eventually causing the whole organ to get larger. -Skeletal muscle hypertrophy in the weight lifter. -Cardiomegaly in response to hypertensive heart disease. Hyperplasia Increase in the number of growth factor cell receptors that activate cellular proliferation. Only happens in cell capable of mitosis. -Increased number of cells. -Uterine and mammary glands in pregnancy. -Increased production of endometrial cells due to estrogen/progesterone imbalance. Dysplasia abnormal changes in cell size, shape or organization in response to cell injury or irritation. Not a true adaptive process. -Cervical dysplasia. Metaplasia Mature cell type is replaced by a different mature cell type. -Reversible, but can induce metestatic change. -Result of chronic stressor to the cell. -Chronic smokers who loose normal ciliated epithelial cells (columnar) and the cells are replaced with squamous cells. -Barrett's esophagus: Normal esophogeal epithelial cells are replaced with columnar type cells that are more like the intestine to withstand the acidity of reflux. hypoxic injury Most common type of cellular injury. Caused by lack of oxygen, loss of hemoglobin, decrease in RBC production, cardiopulmonary disease, ischemia and inflammation. Causes mitochondrial disfunction ↓ decreased ATP production, ↑ anaerobic metabolism, metabolism ceases, cell dies. -Ischemia progresses to hypoxia. Causes intracellular enzymes to show up in labs. -Creatinine kinase - indicates muscle injury. -LDH - muscle, liver, lungs, heart, RBCs and brain. -AST - liver cells -ALT - liver cells -Troponin - heart Reperfusion injury Occurs when O2 supply is restored to ischemic tissues. Causes pH alterations. Trigger reactive oxygen intermediates to be produced causing cell membrane damage and mitochondrial calcium overload. Causes opening of MPTP allowing ATP to escape causing apatosis. Free radical and Reactive Oxygen Species Caused by a molecule with one unpaired electron. They will steal from another electron and cause that electron to become a free radical. ROS can overwhelm the mitochondria (they are a free radical subspecies) -Caused by endothelial injury and leads to atherosclerosis. -ROS have roles in Alzheimers, ALS, Parkinsons. ROS cause lipid peroxidation and destroy the cell membrane. Lipid peroxidation damages proteins and fragments DNA. Ethanol Mood altering CNS depressant. Causes nutrient deficiencies - Magnesium, B6, folic acid, thiamine, phosphorous. Causes inflammation, fatty liver, hepatomegaly and liver failure. -Metabolized by the liver to for acetyaldehyde in the cytoplasm of the cell. -Eventually causes lactic acidosis which prevents gluconeogenesis, increases triglycerides and heapatsteatosis. -Causes the utilization of Acetyl-CoA, causing ketoacidosis and hepatosteatosis. Necrosis Cell death from damage or injury.