Hematology AAB board review questions and answrs(latest upate)

What stains phospholipids, neutral fats, sterols, and also stains marrow fat and some cytoplasmic vacuoles of Burkitt lymphoma. Used for differentiation of AML from ALL Sudan Black B Lymphocytes nucleus is the same size as a __ RBC Which white blood cell inclusion is this? Clear, unstained areas in the cytoplasm Cytoplasmic vacuolization Which white blood cell inclusion is this? Reddish-blue staining needlike inclusions within the cytoplasm Auer rods Which white blood cell inclusion is this? Stacks of rough endoplasmic reticulum that stain light blue Dohle bodies (RNA) Which white blood cell inclusion is this? Large, deep blue-black primary (nonspecific) granules Toxic granulation What white blood cell inclusions are seen in bacterial infections, burns, and leukemoid reactions (chemotherapy) Toxic granulation and vacuoles What white blood cell morphology is seen in infectious mono and other viral infections? Variant lymphs (increased size and basophilia) What do these lab results indicate? - Increased WBC count ( > 50 x 10^9/L) - Left shift - Toxic granulation - Dohle bodies - Vacuolization Neutrophilia or Leukemoid reactions An increased LAP score indicates Leukemoid reaction Reactive neutrophilia & Leukemoid reaction clinical significance Bacterial infections What white blood cell inclusions are seen in reactive neutrophilia and leukemoid reactions? - Toxic granulation - Dohle bodies - Vacuolization What white blood cell inclusion is seen in bacterial infections, burns, and may-hegglin anomaly Dohle bodies In this anomaly you will see azurophilic granules resembling toxic granulation and it is caused by mucopolysaccharidosis Alder-Reilly anomaly This anomaly is a membrane defect of lysosomes with giant abnormal granules and a patient with this anomaly is plagued with albinism and photophobia Chediak-Higashi anomaly In this anomaly you will see hyposegmented neutrophils (bi-lobed nuclei) Pelger-Huet anomaly In this anomaly you will see Dohle bodies, giant platelets, and thrombocytopenia May-Hegglin Anomaly This is described as monocytes above the reference range (> 10%) and can be associated with these conditions: - Syphilis - Brucellosis - Subacute endocarditis - Protozoan and rickettsial infection - Collagen disorders: RA,SLE - Granulomatosis diseases; Crohn's disease Reactive Monocytosis Causes of decreased monocytes (monocytopenia) - Hairy cell leukemia - Prednisone therapy - Most lipid storage diseases What are the lipid storage diseases associated with monocyopenia? - Gaucher's disease - Tay-sachs disease - Nieman-pick disease - Fabry's disease A Betaglucocerebrosidase enzyme deficency characterized by: - Leukopenia - N/N anemia - Thrombocytopenia Gaucher's disease Infectious mononucleosis is caused by this virus Epstein-Barr virus (a herpes virus) These diseases are characterized by pharyngitis, fatigue, and lymphadenopathy - Infectious mononucleosis - Cytomegalovirus infection Infectious mononucleosis is transmitted by __ and is common in people ages __ - Saliva - 17-25 years old Testing for infectious mononucleosis, infectious lymphocytosis, and cytomegalovirus infection is done using what test? Serological monospot What is cytomegalovirus infection is transmitted by? Saliva and blood transfusions If a patient takes the serological monospot test and the test comes back positive the patient has __ Infectious mononucleosis If a patient takes the serological monospot test and the test comes back negative the patient has __ Cytomegalovirus infection or Infectious lymphocytosis This disease is characterized by vomiting, fever, diarrhea, respiratory tract infection and usually occurs in young children Infectious lymphocytosis This leukemia is more common in younger people, has a sudden onset, and has auer rods present. The cells predominantly seen are myeloblasts Acute myelogenous leukemia In acute promyelocytic leukemia (M3) what can occur due to the release of procoagulant substances from the leukemic cells, especially during treatment? Disseminated intravascular coagulation Acute promyelocytic leukemia (M3) treatment Retinoic acid therapy What recurrent chromosomal abnormalities is associated with Chronic myelogenous leukemia? t(9:22) philadelphia chromosome What recurrent chromosomal abnormalities is associated with Acute myeloblastic leukemia with maturation t(8;21) What recurrent chromosomal abnormalities is associated with Acute monocytic leukemia 11q23 Which FAB classification of the acute lymphocytic leukemias has elevated level of terminal deoxynucleotidyl transferase (TdT) ALL occurs most commonly in 2-10 year old's and is characterized by bone and joint pain L1 (common childhood leukemia) A form of leukemia characterized by the accumulation of abnormal, mature lymphocytes and is most common in patients 60+ Chronic lymphocytic leukemia