Risk Assessment

EPA Group A - Human Carginogen - sufficient evidence EPA Group B1 - Probable Human Carcinogen - limited evidence in humans EPA Group B2 - Probable Human Carcinogen - inadequate evidence in humans sufficient evidence in animals EPA Group C - Possible Human Carcinogen - inadequate evidence in animals EPA Group D - Not classifiable as to human carcinogenicity - inadequate animal evidence EPA Group E - No evidence of carcinogenicity in humans.- at least two adequate animal tests or both negative epidemiology and animal studies. How is the daily allowable limit calculated? - CSF/70kg X 20 m3/day (air) or 2 L/day (water) What are the 4 steps in risk assessment - Hazard identification Dose-response assessment Exposure assessment Risk characterization What is a Cancer slope factor? - A value that quantitatively defines the relationship between dose and response. The plausible upper bound estimate of the probability that an individual will develp cancer if eposed to a chemical for a lifetime of 70 years. mg/kg/day What is a hazard? - Capability of substance to cause and adverse affect What is a Risk? - The PROBABILITY that the HAZARD will occur under specific exposure conditions. What is acceptable Daily Intake (ADI)? - Amount of a chemical to which a person can be expose each day for a long time (lifetime) without suffering harmful effects. What is Dos-Response assessment? - characterization of the relation between dose and incidences of adverse effects in exposed populations