CPPS 304 Exam Questions and Answers

CPPS 304 Exam Questions and Answers Receptor - Answer- Macromolecule whose biological function changes when a drug binds to it What are the link between chemical actions and biological function? - Answer- Receptors Emax - Answer- maximum effect of a drug What happens when Emax is reached? - Answer- Emax occurs when all receptors are bound What is in indication that spare receptors are present? - Answer- When Emax is reached before all receptors are bound Agonist - Answer- has affinity for a receptor as well as intrinsic activity at the receptor Antagonist - Answer- has affinity for a receptor but no intrinsic activity at the receptor partial agonist - Answer- has affinity for a receptor but lacks the full intrinsic activity of an agonist inverse agonist - Answer- binds to a constitutively active receptor and inactivates it affinity - Answer- the propensity of a ligand to bind to a receptor high affinity = - Answer- binds readily to a receptor low affinity = - Answer- spends less time bound to a given receptor intrinsic activity - Answer- the action carried out by the ligand while it is bound to a receptor Kd - Answer- dissociation constant (affinity of a drug for a receptor) What does the value of Kd signify? - Answer- measures the propensity of a drug to release (dissociate) from a receptor What does a high Kd mean? - Answer- drug readily dissociates from its receptor What does a low Kd mean? - Answer- suggests high affinity for its receptor If a patient were to overdose on a reversible antagonist, what could you do? - Answer- Add more agonist Irreversible or Non-Competitive Antagonists - Answer- bind to receptor for life Reversible or Competitive Antagonists - Answer- bind and release from a receptor and are in a constant state of flux True or False, increasing the concentration of agonist will overcome the effects of an irreversible antagonist. - Answer- False What are the four types of receptors? - Answer- Ion channel, G-protein coupled, Coupled to enzymes, Intracellular What type of receptor involves Acetylcholine? - Answer- Ion channel What is the fastest type of receptor? - Answer- Ion channel What type of receptor involves adrenergics like epinephrine? - Answer- G-protein coupled What is the most common receptor type? - Answer- G-protein coupled receptor What type of receptor involves receptors dimerizing after being bound by a ligand? - Answer- Coupled to Enzyme Receptors