IBCLC: Pharmacology and Drugs questions well answered 2024

IBCLC: Pharmacology and DrugsAbsorption - correct answer the process by which a drug moves from it's site of admin (extravascular) to the systemic circulation (intravascular) Factors affecting absorption - correct answer solubility characteristics; route of admin; dosage form; peak plasma concentration Factors that affect rate of distribution - correct answer solubility characteristics; molecular weight; plasma protein binding capacity Distribution - correct answer the movement of a medication from the systemic circulation to different tissue sites Lipid solubility - correct answer tendency of a chemical to dissolve in fat, as opposed to in water; lipophilic drugs are more dangerous with a preterm because of low body fat, so drug may accumulate in the brain Molecular weight - correct answer the smaller it is, the more likely it is to cross the membrane and enter the milk; most drugs are 100-300 daltons; Insulin and heparin are very high (>1000 daltons) so very unlikely to pass; Protein binding - correct answer not freely available, so no pharmacologic effect; this would be a positive to have in the drug you are using Milk to Plasma ratio - correct answer concentration of the substance in the milk to the concentration of the same substance in the maternal plasma; related to timing of doses and number of doses; not the same as total amount passed in milk Metabolism - correct answer the process by which the body inactivates the drug; occurs primarily in the liver