Focus on Nursing Pharmacology - Amy M. Karch - Chapter 21 Exam with Complete Solutions 100% Solved

Focus on Nursing Pharmacology - Amy M. Karch - Chapter 21 Exam with Complete Solutions 100% Solved What is main metabolism way of antidepressant? - answerHepatic metabolism Substrate of CY2D6? - answerTCA, venlafaxine Inhibitor of CYP2D6? - answerParoxetine Sertraline Fluoxetine Citalopram Duloxetine Inhibitor of CYP3A4 - answerFluoxetine Nefazodone Inhibitor of CYP1A2 - answerFluvoxamine What is CYP2D6 polymorphism? - answerDifferent patient will have from normal to different genetic mutation that affect drug being metabolism by CYP2D6 Need a dose adjustment to avoid overdose, esp with TCA What is the SE of SNRI? - answer1) Similar to SSRI, with anticholinergic effect ( hypertensive, tachycardia due to increase norepinephrine) - esp with venlafaxine 2) Hepatoxicity - esp with Duloxetine 3) CNS stimulation ( Anxiety, insomnia, agitation ) MOA of TCA drugs? - answerSimilar to SNRI with additional blockage of H1, adrenergic, cholinergic