FULL TEST BANK For Lehninger Principles of Biochemistry by David L. Nelson Questions And Answers latest Update Graded A+

46. Which method of directly regulates PFK-I? A) feedback inhibition by fructose 2,6-bisphosphate B) feed forward activation by phosphoenolpyruvate C) allosteric activation by AMP D) its phosphorylation in response to glucagon signaling E) allosteric activation by citrate 47. Which statement regarding regulation of glycolysis and gluconeogenesis is FALSE? A) Phosphofructokinase-1 and fructose 1,6-bisphosphatase are PRevented from forming a futile cycle by reversible covalent modification. B) Hexokinase IV and glucose 6-phosphatase are transcriptionally regulated in hepatocytes. C) Phosphofructokinase-1 and fructose 1,6-bisphosphatase are reciPRocally regulated by the allosteric regulator, fructose 2,6-bisphosphate. D) Binding of fructose 2,6-bisphosphate to phosphofructokinase-1 reduces the affinity of this enzyme for citrate. E) The cellular concentration of fructose 2,6-bisphosphate is determined by a bifunctional enzyme that is hormonally regulated. 48. Which metabolic effect is associated with AMP-activated PRotein kinase (AMPK)? A) When activated, AMPK stimulates insulin release from the pancreas. B) When activated, AMPK activates fructose 2,6-bisphosphatase. C) When activated, AMPK stimulates glucose uptake in cardiac and skeletal muscle. D) When activated, AMPK both activates fructose 2,6-bisphosphatase and stimulates glucose uptake in cardiac and skeletal muscle. E) None of the answers is correct. 49. Which factor affects the activity of glucokinase in hepatocytes? A) transcriptional regulation B) subcellular localisation C) association with a regulatory PRotein D) transcriptional regulation and subcellular localisation E) All of the answers are correct. 50. Which enzyme is used in both glycolysis and gluconeogenesis? A) 3-phosphoglycerate kinase B) hexokinase C) glucose 6-phosphatase D) phosphofructokinase-2 E) pyruvate kinase