NR546 WEEK 1
The amygdala is associated with anxiety and perception of odors.
The hippocampus is involved in memory and anxiety. The amygdala is associated with anxiety and
perception of odors. The prefrontal cortex is associated with executive function. The thalamus is
associated with motor command processing
The client’s cognitive status can result in an ethical concern if the client is unable to self-determine
care or is a danger to self or others. Ability to pay is not an ethical issue.
basal ganglia are a group of structures involved in voluntary motor movements. Basal ganglia are also
involved in cognition and emotion.
Limbic system is associated with emotion and learning
hippocampi are associated with long term memory
Wernicke's area is associated with speech comprehension. Review activity
the dorsolateral prefrontal cortex (DLPFC) is concerned with higher level functioning. The VLPFC is
involved with motor inhibition the IFG contains Broca's area which is associated with speech production
understanding grammar. Pliska Ch. 8
the OFC is involved in decision making and social behavior with a focus on punishment and rewards. The
OFC inhibits and activates the amygdala and is activated when a risk assessment is required. Some
behaviors associated with the OFC include sex, sugar, pain, social humiliation, money, rewards, fame,
and aggression. The amygdala will identify a threat and then the OFC will determine the risk or benefit of
an action based on past experience. Pliska Ch. 8, p.158
At this time, 20 % of the world’s population is suffering from a neurologic and/or psychiatric disorder.
Week 2 Quiz
G protein linked systems, one of the signal transduction cascades, pass the message from a first receptor
to a second messenger .
Glutamate is an excitatory neurotransmitter. (NEI glutamate video- the glutamate sisters)
CYP 3A4 is one of the 5 most important NT which include CYP 1A2, 2D6, 2C9, 2C19, 3A4. Dosing
adjustments may be required. Stahl p. 46-51.
Smoking induces CYP1A2. Stahl p.48
partial agonist- drug does not fully activate receptors; antagonist- drug binds to receptor but does
not activate a response; inverse agonist- drug cause opposite effect of the agonist ;agonist- ;agonist-
drug binds to the receptor and activates a biological response
G protein Linked systems and ion channel linked cascades are triggered by neurotransmitters. Stahl p. 11
, Propagation of an action potential to the axon terminal is mediated by voltage-sensitive sodium
channels. Influx of sodium through voltage-sensitive sodium channels at the axon terminal leads to
opening of voltage-sensitive calcium channels, also at the axon terminal. Influx of calcium through the
open voltage sensitive calcium channels leads to docking of synaptic vesicles and secretion of
neurotransmitter into the synapse.
Agonists cause ligand-gated ion channels to open more frequently.
The communication between neurons at synapses is mediated by neurotransmitter molecules and is
therefore chemical. Stahl p. 6
Transcription factors are proteins that bind to promoter sequences of DNA to turn gene expression on
and off.
chemical neurotransmission is the foundation of psychopharmacology
NR546 Week 3
EPSs manifest when dopamine receptor occupancy within the basal ganglia reaches approximately
80% as the dopamine-mediated inhibition of movement is now disinhibited (Refer to pathophysiology
and the basal ganglia model of movement)Stahl p.133 . See figure 5-4
Risperidone has the highest risk for galactorrhea. Review tuberofundiular pathway Stahl p.95
clozapine is documented to decrease risk of suicide in schizophrenic clients. Stahl p. 181
"Aripiprazole is associated with the lowest risk weight gain.
All pines are associated with weight gain. Though not associated with large weight gain, lurasidone is not
associated with less weight gain in the same way as aripiprazole. Week 3 lecture "
Haldol is a first-generation antipsychotic, which can cause a dystonic reaction. Clozapine is one of the
only antipsychotics that does not cause dystonia. The other medications are not known for causing
dystonia.