Cancer Questions Only from - ABGC Practice Test 1 - 02/2024 (100% solved)

A 45yearold man with colon cancer comes for genetic counseling. In conjunction with microsatellite instability testing, which of the following tests done on his colon tumor would be MOST helpful in deciding about testing for germline Lynch syndrome mutations? A. comparative genomic hybridization B. tumor cell karyotype C. immunohistochemical staining D. loss of heterozygosity correct answers C. immunohistochemical staining A 43yearold woman seeks genetic counseling because of a recent diagnosis of endometrial cancer. Her family history includes a maternal grandmother with breast cancer at age 56, father with colorectal cancer at age 47, and one paternal aunt with ovarian cancer at age 49. Counseling regarding testing for which of the following syndromes is MOST appropriate? A. familial adenomatous polyposis B. hereditary breast and ovarian cancer C. hereditary nonpolyposis colorectal cancer D. PTEN hamartoma tumor syndrome correct answers C. hereditary nonpolyposis colorectal cancer A 30yearold woman with a family history of breast cancer comes to the genetics clinic for BRCA1 and BRCA2 testing. Her mother was diagnosed with breast cancer at 45. Her family history also includes a paternal aunt with breast cancer diagnosed at 68 and a maternal first cousin with breast cancer diagnosed at 35. To clarify the woman's risk, which of the following individuals should be tested FIRST? A. the paternal aunt B. her mother C. her other paternal aunt who has no history of cancer D. the maternal first cousin with breast cancer correct answers B. her mother A couple comes for preconception genetic counseling because the woman had bilateral retinoblastoma. The husband asks about his wife's risks for developing the nonocular cancers associated with this disease. The counselor invites the woman to answer in an attempt to assess her level of understanding and perception of risk. She responds in anger, "Do you mind not talking about this?!" Which of the following is the MOST appropriate response by the genetic counselor? A. Explain that her reaction may be a healthy coping mechanism. B. Acknowledge her anger and ask her to elaborate on her reaction. C. Discuss information regarding her increased risk of additional cancers. D. Offer to talk to the husband later in private and redirect the conversation. correct answers B. Acknowledge her anger and ask her to elaborate on her reaction.