Advanced Pharmacology NSG 533 Pass test 2023 100% CORRECT

On your way to this examination, you experience the vulnerable feeling that an attack of acute diarrhea is imminent! If you stop at a drug store, which anti-diarrheal drugs could you buy without a prescription even though it is chemically related to the strong opioid analgesic meperidine (but acts only on the peripheral opioid receptor)? - CORRECT ANSWER Loperamide JA has multiple medical problems and is taking several drugs including theophylline, warfarin and phenytoin. His conditions were well controlled, but recently he started to experience some GI distress for which of his "well intentioned friends" gave him some medication. He presents to you with toxic effects of all his other medications and plasma levels of those medications elevated. What was most likely the medication he took? - CORRECT ANSWER Cimetidine What lifestyle modifications should be recommended? - CORRECT ANSWER -losing weight if overweight -elevating head of bed while asleep -eating smaller meals -avoid foods/meds that exacerbate gerd -stop smoking -stop drinking alcohol What medications / foods can contribute to GERD? - CORRECT ANSWER - Medications: anticholinergics, barbituates, dopamine, estrogen, opioids, progesterone, theophylline, nitrates -Foods: cirus fruits/juices, coffee, tomatoes, spicy food, carbonated drinks Fried/fatty foods, garlic, onions, chocolate What is the most effective PPI or H2RA within each of these classes? - CORRECT ANSWER -PPI- bismuth quadruple therapy combined with proton pump inhibitors -H2RA- Famotidine 80mg Other products such as antacids are also available. What are some of these and what is their place in therapy? - CORRECT ANSWER -Reflux symptoms 2 times a week (infrequent) -Effective for immediate relief -Magnesium/Aluminum Hydroxide (Maalox)- can cause constipation -Alginic Acid Why would antibiotics be used for PUD caused by H Pylori? What is a typical regimen and duration of therapy? What patient specific factors should be considered and how should treatment be monitored? - CORRECT ANSWER Considerations before regimen choice: -penicillin allergy -previous exposure to macroglide antibiotics Strongest Reccomendation: -Bismuth Quadruple Therapy 10-14 days *do not drink alcohol w/ metronidazole* -Salvage regimen should be different than first regimen