Glycolysis (Occurs in Cytoplasm): Glycolysis (Occurs in Cytoplasm):
Glucose (6C) has two phosphate groups added
to it by the hydrolysis of 2 ATP molecules:
ATP ADP + P
This forms hexose bisphosphate (6C).
Hexose bisphosphate splits into two molecules
of triose phosphate (3C).
2H are removed from each molecule of triose
phosphate by a dehydrogenase enzyme.
An NAD molecule is converted to a reduced
NAD molecule:
NAD + H Reduced NAD
The phosphate groups are removed & 2 ATP
molecules are generated from ADP & P:
ADP + P ATP
This is substrate level phosphorylation of triose
phosphate (3C) to form pyruvate (3C).
The net products of glycolysis are:
2 Pyruvate molecules (3C).
2 Reduced NAD.
2 ATP.
The Link Reaction (Occurs in the The Link Reaction (Occurs in the
Mitochondrial Matrix): Mitochondrial Matrix):
Each Pyruvate (3C) is decarboxylated by
pyruvate decarboxylase to remove CO2.
2H are removed by pyruvate dehydrogenase &
NAD molecules are converted to reduced NAD
molecules:
NAD + H Reduced NAD.
This forms two molecules of acetate (2C).
Coenzyme A combines with each acetate to
form two acetyl coenzyme A.
The Net products are:
Glucose (6C) has two phosphate groups added
to it by the hydrolysis of 2 ATP molecules:
ATP ADP + P
This forms hexose bisphosphate (6C).
Hexose bisphosphate splits into two molecules
of triose phosphate (3C).
2H are removed from each molecule of triose
phosphate by a dehydrogenase enzyme.
An NAD molecule is converted to a reduced
NAD molecule:
NAD + H Reduced NAD
The phosphate groups are removed & 2 ATP
molecules are generated from ADP & P:
ADP + P ATP
This is substrate level phosphorylation of triose
phosphate (3C) to form pyruvate (3C).
The net products of glycolysis are:
2 Pyruvate molecules (3C).
2 Reduced NAD.
2 ATP.
The Link Reaction (Occurs in the The Link Reaction (Occurs in the
Mitochondrial Matrix): Mitochondrial Matrix):
Each Pyruvate (3C) is decarboxylated by
pyruvate decarboxylase to remove CO2.
2H are removed by pyruvate dehydrogenase &
NAD molecules are converted to reduced NAD
molecules:
NAD + H Reduced NAD.
This forms two molecules of acetate (2C).
Coenzyme A combines with each acetate to
form two acetyl coenzyme A.
The Net products are:
