NUR-641E Advanced Pathophysiology and Pharmacology for the Nurse Educator Revised Study Guide 2024

NUR-641E Advanced Pathophysiology and Pharmacology for the Nurse Educator Revised Study Guide 2024 1. Pharmacokinetics: Involves ADME (absorption, distribution, metabolism and elimination). Absorption: absorption from the administration site either directly or indirectly into the blood/plasma. Distribution: reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid. Metabolism: bio-transformed via hepatic metabolism or by other tissues. Elimination: lastly, the drug & its metabolites are eliminated from the body 2. The route of administration with the highest bio-availability is: Intravenous; putting entire dose into a patient's vein and bypassing absorption. Intravenous route avoids first-pass metabolism in the liver. 3. rectal administration disadvantages: variable and erratic absorption 4. Steady state (SS): is usually reached within 4-5 half-lives of a drug