Pharmacology LMU DCOM Antimicrobials questions with 100% correct answers graded A+ 2023/2024

Pharmacology LMU DCOM Antimicrobials Bacterial Cell Wall Agents - correct answer Agents Kill when walls are synthesizing Inhibitors of Murein Monomer Synthesis - correct answer Fosfomycin Cyclomerize Bactrian Fosfomycin** - correct answer Effective Against G- bacteria in the urinary Tract (single dose) enters cell via transporters for glycerophosphate or glucose 6 phosphate Resistance is caused by mutation in the transporters excreted unchanged in urine cycloserine - correct answer Second line agent for TB S/e: seizure, neurological syndrome, psychosis Bacitracin - correct answer S/E: kidney, neuro, bone marrow toxicity not used systemically VERY TOXIC Inhibitor of Murein Polymerization: - correct answer Glycopeptides: Vancomycin*** Telavancin (not in US) Daptomycin Glycopetides MOA: - correct answer bind or D ALA D ALA of muerin monomer, inhibiting peptidylglycan Vacomycin: absorption - correct answer not oral used only orally for c diff (2nd line) Vancomycin: SE - correct answer RED MANS SYNDROME: with rapid IV infusion flushing and itching non-IG mediated mast cell degranulation and histamine release. NEPHROTOXIC AND OTOTOXIC when givin IV Vancomycin Safe in Pregnancy - correct answer Yes! Vancomycin: Monitoring - correct answer renally cleared and requires monitoring of the trough Telavancin - correct answer inhibits cell wall synthesis and disrupts cell membrane gram+ rods and cocci with MRSA SE: foamy urine. taste distrubance non-inferior to vancomycin and cost more Vacomycin: use - correct answer MRSA gram + rods and cocci Daptomycin - correct answer IV gram + only