Maryville Pharm 615 Exam 4 Study Set Questions 100% Correct

Tiotropium/Spiriva is a long acting ____________________ used in the maintenance of __________________ -ANSWER 1. Antimuscarinic/Anticholinergic 2. COPD What is the action of Tiotropium (long acting antimuscarinic agent) -ANSWER It is a smooth muscle relaxer and it decreases submucosal glands. This leads to reduction of smooth muscle contraction and mucus secretion. What are adverse reactions to Singulair/Montelukast that you need to teach patients about? -ANSWER Aggression, depression, anxiety, suicidal thoughts What ethnic population should not take long acting beta agonists? -ANSWER African American Why should African Americans not take LABAs? -ANSWER Some asthmatics are Homozygous for variant in the 16th amino acid position on the beta 2 receptor. Taking this medication might worsen air flow and asthma control. There are more african americans with this variant. What inhaled medication would you prescribe to a patient that is taking propranolol? -ANSWER Ipratropium/Atrovent How does albuterol work? -ANSWER It is a short acting beta agonist. Produces 2nd messenger cAMP. This hyperpolarizes smooth muscle cells. It decreases calcium and increases potassium conduction, leading to smooth muscle relaxation and bronchodilation How do corticosteroids work? -ANSWER They produce an anti-inflammatory and vasoconstriction effect. They inhibit the cells responsible for inflammation like eosinophils, neutrophils, macrophages, cytokines, etc. What is the difference between short acting and long acting beta agonist? -ANSWER Short acting can be used like a rescue inhaler for acute attacks. Long acting are used to prevent exacerbations.