WGU D027 pathopharm Exam Questions

Mechanism of Action for loop diuretics - Answer- block water reasborption in the loop of Henle of nephron. Increases urine output Suffix for loop - Answer- -emide ex: furosemide cautions in using loop diuretics - Answer- decreased potassium, decreased BP, ototoxicity, nephrotoxicity USE WITH CAUTION in those who have auditory/renal impairments Suffix for Thiazide Diuretics - Answer- -thiazide MOA for thiazide diuretics - Answer- blood water reabsorption in distal tube of nephron-- increases urine output adverse drug reactions for thiazide diuretics - Answer- decreases potassium, increases uric acid, increases calcium AVOID use in hx with gout, use cautiously with kidney disease Contraindicator for thiazide diuretics - Answer- those with sulfa allergies, contains sulfa group in molecular structure. Also avoid in hx of gout due to increase of uric acid Aldosterone antagonists MOA - Answer- inhibits aldosterone which results in sodium loss in the nephron, water follows and is excreted, potassium is retained (potassium sparing diuretic) example of an aldosterone antagonist - Answer- Spironolactone