ABCP exam 2023 with 100% correct answers

What is the defect associated with Malignant Hyperthermia - correct answer it's an autosomal defect of Ryanodine subtype 1 receptor, RY1 on chromosome 19 What is RY1 responsible for? - correct answer contraction and coupling in skeletal muscle What are triggers for Malignant Hyperthermia? - correct answer depolarizing muscle relaxants: succinylcholine and hologenated inhalation gases What is the most common need for surgery during pregnancy? - correct answer MS (mitral stenosis) What is optimal timing for pregnant pt? - correct answer 2nd trimester (14-26 wks) because fetus organs are formed and fetus maybe viable. What pump flows and MAP should be maintained for pregnant pt on CPB? - correct answer maintain fetal oxygenation , MAP>50mmHg, 2.5 L/min desirable (70 and up to 3.4 L/min can be good) What type of flow is preferable for pregnant pts? - correct answer Pulsitile flow prevents drop in UBF and limits rise in uterine vascular resistance (UVR) What temp should a pregnant patient be kept? - correct answer maintain 35+ degrees because hypothermia decreases O2 exchange through placenta, provokes uterine contractions and decreases placental BF What are CPB considerations for Sickle cell disease - correct answer 1) don't induce sickle cell crisis via HYPOXIA, VASCULAR STASIS, HYPEROSMOLARITY, ACIDOSIS 2) avoid hyperthermia: causes vasoconstriction, venous stasis 3) Only crystalloid CPG to flush HbS from coronaries What are