Lung Pathology questions with accurate answers (graded A+

What is involved in Cushing's Syndrome? - Answers-increased ACTH, bilateral adrenal hyperplasia, moon face, buffalo hump, weight gain, sweating, striations on the skin, telangiectasia, baldness, insomnia Patients who have adenocarcinoma with mutations in the EGFR gene respond to what treatment? - Answers-Tyrosine Kinase Inhibitors (Gefitinib and Erlotinib) (and they respond to pemetrexed) In what patients is Bevacizumab contraindicated? - Answers-Squamous cell carcinoma patients Causes hemorrhage, life threatening bleeds When would a patient with adenocarcinoma respond poorly to tyrosine kinase inhibitors? - Answers-if they had a Kras mutation (the two mutations are mutually exclusive, will only have one or the other) What is used to treat patients with a Kras mutation and how does it work? - Answers-Crizotinib inhibits the EMNL4/ALK fusion protein (which is found in 45% of NSCLC) What is diffuse pulmonary neuroendocrine cell hyperplasia (DIPNEC) related to? - Answers-Carcinoid tumors