NURSING MSN 571 PHARM-MIDTERM- FINAL EXAM QUESTIONS AND ANSWERS |ALREADY GRADED A

What intervention does the provider take to decrease risk to the patient when prescribing drugs with a narrow therapeutic index? -ANS-- drugs with narrow therapeutic range are more dangerous, provider who is aware of this fact can focus additional attention on monitoring these patients for signs and symptoms of toxicity definition of onset of action -ANS-- Onset of Action: the time it takes a drug to reach the minimum effective concentration after a drug is administered. definition of bioavailability -ANS-- Bioavailability: the amount of an active drug that reaches the systemic circulation from its site of administration. Disintegration time, extended release, capsule coatings, can all effect this. Greatest concern is with drugs that have a narrow therapeutic index. IV administration results in the highest bioavailability. definition of protein binding -ANS-- Plasma protein binding refers to the degree to which medications attach to proteins within the blood. A drug's efficiency may be affected by the degree to which it binds. The less bound a drug is, the more efficiently it can traverse cell membranes or diffuse. definition of loading dose -ANS-- Loading dose: a large initial dose of the drug is given to achieve a rapid minimum effect concentration in the plasma.