Lippincott's Pharmacology Chapter 1 questions with correct answers

Passive Diffusion - Answer High conc. -> low majority of drugs work this way does not involve carrier, is not saturable, and shows a low structural specificity Facilitated Diffusion - Answer involves carrier proteins High conc -> low no energy required, an be saturated, may be inhibited by compounds that compete for the carrier Active Transport - Answer Shows saturation kinetics for the carrier drugs closely resemble naturally occurring metabolites that are actively transported across cell membranes may be competitively inhibited exo/endocytosis - Answer B12 is absorbed by endocytosis; some neurotransmitters (e.g., norepinephrine) are stored in vesicles and released by exocytosis Distribution equilibrium - Answer when the permeable form of a drug achieves an equal concentration in all body water space P-glycoprotein - Answer a multidrug transmembrane transporter protein responsible for transporting various molecules , including drugs, across cell membranes; in areas of high expression, it reduces drug absorption