NU 641 Mental Health Anridepressants Questions With Complete Solutions

Tricyclic Antidepressants (TCAs) examples: correct answer: Amitriptyline (Elavil), nortriptyline (Pamelor), imipramine (Tofranil), doxepin (Sinequan), desipramine (Norpramin), clomipramine (Anafranil) Why TCAs are not first line treatment? correct answer: Nonselective (more side efffects) Norepinephrine-Serotonin Reuptake Inhibitors Equally efficacious as other antidepressants but have greater side effects, less safe in suicidal population-overdose can be fatal TCAs MOA correct answer: Inhibit reuptake of serotonin and norepinephrine at presynaptic neuron Also act on histamine (drowsiness, weight gain) and acetylcholine TCAs ADRs correct answer: ADR's: paradoxical diaphoresis, causing anticholinergic effects, orthostatic hypotension, sedation, drowsiness TCAs are Contraindicated/caution in correct answer: Contraindicated/caution in cardiovascular disorders, glaucoma, prostatic hypertrophy, or urinary incontinence, seizure disorders, elderly What other medication cannot be taken concurrently with TCAs? correct answer: Do not prescribe with MAOIs Can TCAs be used in pregnancy? correct answ