Practical Management of DOACs & Warfarin questions with correct answers

Following Up on DOACs: Checklist - Answer - Compliance: check adherence and educate on importance - Thromboembolism: check for recurrence of clotting - Bleeding: educate on bleed prevention and management - Other ADRs: no many - Co-Medications: check for DDIs Blood Sampling: renal & hepatic Functions Drug Interactions Considerations: Warfarin - Answer - Interacting drugs are NOT contraindicated - Can be managed through increased INR monitoring and dose adjustments Drug Interactions Considerations: DOACs - Answer - Drug interactions are contraindications/precautions - No ability to monitor and adjust dose (less interactions though) DOACs Drug Interactions - Answer DDIs increase the risk of bleeding or clotting - monitor for bleeding - may want to avoid combo with inducers (ineffectiveness) DOACs Drug Interactions: CYP3A4 Inducers (some of them) - Answer Carbamazepine, GCs, Phenobarbital, Phenytoin, Primidone, Rifampin, St. John's Wart