ASCP(MB) Exam Questions with correct Answers

BCR-ABL - Answer- Genes involved in cancer caused by t(9;22) CML - Answer- Cancer caused by t(9:22) EWS-FLI1 - Answer- Genes involved in cancer caused by t(11;22) Ewing sarcoma - Answer- Cancer caused by translocations involving 22q12 HER2(ERBB2) - 17q21.1 - Answer- Receptor tyrosine kinase commonly overexpressed in breast cancer IHC, rtPCR, FISH - Answer- Methods used to assess overexpression of common oncogenes KRAS - Answer- Most common oncogene in human cancer, which activates MAPK pathway t(11,22)(q24,q12) - Answer- Most common translocation in 85% of Ewing's sarcoma Synovial sarcoma - Answer- 80% of this type of cancer is caused by t(X;18) FKHR (FOXO1A) - Answer- Gene on chromosome 13 that is involved in translocations in rhabdomyosarcoma TP53 - Answer- Inherited mutations in this gene cause Li-Fraumeni syndrome ATM - Answer- Gene mutated in Ataxia Telangiectasia