Abnormalities of Haemostasis and Thrombosis - Summary Notes

Haemostasis/
Thrombosis
Haemostasis-blood vessel response to injury, forming a clot to limit
haemorrhage.


Primary
components of Clot:
·
Quicker 5mins. -

Platelets
WF
-




·
Platelet
aggregation at damaged area (Platelets + vWF). -




Clotting Factors
le.g. Prothrombin, Fibrinogen)
von Willebrand Factor (VWF) -


facilitates
aggregation
and adhesion platelets
of to
collagen damage site.
of THROMBUS FORMATION
cleared/lysed by ADAMPTS13 protease.
·




Defect
symptoms:

Menorrhagia non-blanching Purpura/Petechiae
- -




Epistaxis -excess
bleeding after cuts
-




-Easybruising Organomegaly
-




Disorders:
PURPURA
·
Von Willebrand Disease (vWD):

Type 1:partial vWIdeficiency, not overly problematic.
·




Type 2:normal quantity, butabnormal UWE function.
·




Type :complete vWF absence, causing severe bleeding.
·




·
PlateletDisorders:

1vs 2 HAEMOSTASIS SYMPTOMS
Gray Syndrome, Storage Pool Disease:
Platelet
·




reduced granule secretion from platelets.


·
Bernard-Soulier Syndrome, Glanzmann's Thrombasthenia:
deficiencies mean platelets
cannot bind WWE
and
aggregate adhere.

·Thrombocytopenia:·Causes:
-

Leukaemia
low plateletcount. Myeloma
· -




Aplastic Anaemia
-




Bone Marrow Failure
-




Malaria
-




Drugs:Aspirin, Clopidogrel
-