SCD questions with correct answers

Can fetal RBC be sickle shape? - Answer No Can mothers RBC be sickle shape? - Answer Yes What is the HbSS form of sickle cell disease? - Answer They inherit 2 sickle cell genes 1 from each parent HbSS = sickle cell anaemia *most severe form* What is sickle cell crisis? - Answer Several independent acute conditions which occur in patients with SCD. SCD --> anaemia + many other crises What is sequestration crisis? - Answer Sequestration crises results from trapping of large amounts of red cells in the spleen and sometimes in the liver *important cause of early mortality in children with SCD What are the causes of death in SCD? - Answer 1. Acute chest syndrome 2. Bacterial infection 3. Acute splenic sequestration 4. Chronic renal failure 5. Cerebrovascular accident 6. Multiorgan failure with intravascular sickling 7. Stroke