Lehne's Pharmacotherapeutics Goldfarb School of Nursing-Spring 2022 Ch: 1-11 QUIZ BANK Complete2023 VERIFIED

Lehne's Pharmacotherapeutics Goldfarb School of Nursing-Spring 2022 Ch: 1-11 QUIZ BANK Complete2023 VERIFIED Pharmacokinetics correct answers the movement of drugs and their metabolites through the body from absorption to excretion--what the body does to the drug 4 pharmacokinetic processes correct answers drug absorption, drug distribution, drug metabolism, drug excretion drug absorption correct answers entrance of a drug into the bloodstream from its site of administration drug distribution correct answers passage of a drug from the blood to the tissues and cells of the body drug metabolism correct answers also known as bioremediation. the enzymatic alteration of drug structure. drug excretion correct answers The process by which a drug and/or its waste products are eliminated from the body. drugs can be excreted via urine, sweat, saliva, expired air, breast milk Overall action of pharmacokinetics correct answers the processes act in concert to determine the concentration of a drug at its sites of action (receptor sites) movement of drugs throughout the body correct answers 1. passing through channels and/or pores 2. passing through the cell membrane with aid of cell membrane transport system **3. penetrating the membrane directly **most common Pharmacodynamics correct answers what drugs do to the body and how they do it dose-response relationship correct answers the relationship between the size of an administered dose and the intensity of the response produced--the higher the dose the stronger the response therapeutic index correct answers the ratio of the drug's LD50 (avg lethal dose) and its ED50 (avg effective dose) as determined by drug trials. is a measure of drug safety. **the wider the index the safer the drug** receptor correct answers any functional macromolecule in a cell which a drug binds to produce its effects, usually reversible cell membrane embedded enzymes correct answers Receptors that span the cell membrane; domain is located on the cell surface with the enzyme's catalytic site inside; response occurs in seconds. i.e. insulin ligand gated ion channels correct answers Transmembrane protein that opens to allow the passage of a specific charged ion across the membrane when a specific signal molecule binds to the extracellular side of the protein. action occurs in milliseconds. i.e. GABA, acetylcholine G protein-coupled receptor systems correct answers An endogenous ligand or agonist drug activates receptor => activates G protein => activates effector. i.e. serotonin, histamine