School of Medical Sciences
Pharmaceutical and Chemical Engineering Department
Laboratory Manual
For
P HYSICAL C HEMISTRY L AB
M ANUAL
PCE272
Edition: 2021
, Contents
Experiment 1 ......................................................................................................... 1
Partial Molar Volume ............................................................................................ 1
Experiment 2 ......................................................................................................... 6
Boiling Point Elevation .......................................................................................... 6
Experiment 3 ....................................................................................................... 11
Salt Effect On Solubility And Dissociation ........................................................ 11
Experiment 4 ....................................................................................................... 15
Reaction Rate and Activation Energy of the Acid Hydrolysis of Ethyl Acetate
................................................................................................................................ 15
Experiment 5 ....................................................................................................... 20
Adsorption Isotherm ............................................................................................ 20
Experiment 6 ....................................................................................................... 25
Binary water - phenol mixture............................................................................ 25
Experiment 7 ....................................................................................................... 31
Ternary systems ................................................................................................... 31
Experiment 8 ....................................................................................................... 39
Determination of Distribution Coefficient of I2 and Stability Constant of I3-
Complex ................................................................................................................ 39
Experiment 9 ....................................................................................................... 43
Transfer of salicylic acid across polymeric membrane .................................... 43
Experiment 10 ..................................................................................................... 47
Critical Micelle Concentration ........................................................................... 47
, Preface and Safety
Preface and safety
Course Objectives and Learning Outcomes
The practical part is designed to achieve a working knowledge through examination of some of the basic
physicochemical principles covered in the lectures of CPE2282 in the delivery of drug and the design of
pharmaceutical dosage forms.
Teaching and Learning Methods
Teaching Methods:
Demonstration and general explanation
Course Content
No. of
Topic
Lab.sessions
Syllabus –Introduction, Safety regulations 1
Partial Molar volume 1
Boiling Point Elevation 1
1
Salt effect on solubility and dissociation effect
Reaction Rate and Activation Energy of the Acid Hydrolysis of Ethyl Acetate 1
Adsorption isotherm 1
Binary and ternary systems 3
Transfer of salicylic acid across polymeric membrane: Diffusion phenomenon 1
Determination of Distribution Coefficient of I2 and Stability Constant of I3-
1
Complex
Critical Micelle Concentration 1
Assessment Policy*
Type Weight (%)
Reports and quizzes 60%
Final Exam(practical-theoretical) 40 %
*Make-up exams will be offered for valid reasons only with consent of the Dean. Make-up
exams may be different from regular exams in content and format.
I
, Preface and Safety
Regulations
Attendance There is one laboratory session per week (3 hours).
Laboratory attendance is MANDATORY (NOT optional), unless special
arrangements are made with your instructor (no more than two sessions),
accompanied by a valid excused absence. There will be no make-up laboratories.
The student will lose 5 marks of the total course grade for each missed laboratory
session.
Students are not allowed to leave the laboratory during the session without obtaining
permission, to minimize their absence.
The week’s experimental procedure will be sent periodically by e-mail.
Laboratory Students are required to read carefully the experimental procedure before coming to
notebook: the lab.
The lab report with completed lab work should be submitted to the lab TA at the end
of each lab session in order to be signed and graded.
-Lab Safety Lecture
Safety A mandatory introductory safety lecture FOR ALL GROUPS will be held on first
measures: session
Each student must wear a clean, white laboratory coat at all times while in the
laboratory.
Each student must have a clean towel on hand at all times to keep his place or tools
clean.
All equipment and bottles should be returned to the proper place after use.
Assume all chemicals used in the experiment are dangerous.
Eating or drinking in the laboratory is prohibited.
Do not pipette by mouth or carry reagents around the lab.
Wash your hands thoroughly before leaving the lab.
Take time to review the laboratory safety section and locate the following safety
equipment in the laboratory.
Safety Equipment Location
Fire Extinguishers
Fire Alarm
Eye Wash Fountains
Safety Shower
First Aid Box
Chemical Disposal
II
Pharmaceutical and Chemical Engineering Department
Laboratory Manual
For
P HYSICAL C HEMISTRY L AB
M ANUAL
PCE272
Edition: 2021
, Contents
Experiment 1 ......................................................................................................... 1
Partial Molar Volume ............................................................................................ 1
Experiment 2 ......................................................................................................... 6
Boiling Point Elevation .......................................................................................... 6
Experiment 3 ....................................................................................................... 11
Salt Effect On Solubility And Dissociation ........................................................ 11
Experiment 4 ....................................................................................................... 15
Reaction Rate and Activation Energy of the Acid Hydrolysis of Ethyl Acetate
................................................................................................................................ 15
Experiment 5 ....................................................................................................... 20
Adsorption Isotherm ............................................................................................ 20
Experiment 6 ....................................................................................................... 25
Binary water - phenol mixture............................................................................ 25
Experiment 7 ....................................................................................................... 31
Ternary systems ................................................................................................... 31
Experiment 8 ....................................................................................................... 39
Determination of Distribution Coefficient of I2 and Stability Constant of I3-
Complex ................................................................................................................ 39
Experiment 9 ....................................................................................................... 43
Transfer of salicylic acid across polymeric membrane .................................... 43
Experiment 10 ..................................................................................................... 47
Critical Micelle Concentration ........................................................................... 47
, Preface and Safety
Preface and safety
Course Objectives and Learning Outcomes
The practical part is designed to achieve a working knowledge through examination of some of the basic
physicochemical principles covered in the lectures of CPE2282 in the delivery of drug and the design of
pharmaceutical dosage forms.
Teaching and Learning Methods
Teaching Methods:
Demonstration and general explanation
Course Content
No. of
Topic
Lab.sessions
Syllabus –Introduction, Safety regulations 1
Partial Molar volume 1
Boiling Point Elevation 1
1
Salt effect on solubility and dissociation effect
Reaction Rate and Activation Energy of the Acid Hydrolysis of Ethyl Acetate 1
Adsorption isotherm 1
Binary and ternary systems 3
Transfer of salicylic acid across polymeric membrane: Diffusion phenomenon 1
Determination of Distribution Coefficient of I2 and Stability Constant of I3-
1
Complex
Critical Micelle Concentration 1
Assessment Policy*
Type Weight (%)
Reports and quizzes 60%
Final Exam(practical-theoretical) 40 %
*Make-up exams will be offered for valid reasons only with consent of the Dean. Make-up
exams may be different from regular exams in content and format.
I
, Preface and Safety
Regulations
Attendance There is one laboratory session per week (3 hours).
Laboratory attendance is MANDATORY (NOT optional), unless special
arrangements are made with your instructor (no more than two sessions),
accompanied by a valid excused absence. There will be no make-up laboratories.
The student will lose 5 marks of the total course grade for each missed laboratory
session.
Students are not allowed to leave the laboratory during the session without obtaining
permission, to minimize their absence.
The week’s experimental procedure will be sent periodically by e-mail.
Laboratory Students are required to read carefully the experimental procedure before coming to
notebook: the lab.
The lab report with completed lab work should be submitted to the lab TA at the end
of each lab session in order to be signed and graded.
-Lab Safety Lecture
Safety A mandatory introductory safety lecture FOR ALL GROUPS will be held on first
measures: session
Each student must wear a clean, white laboratory coat at all times while in the
laboratory.
Each student must have a clean towel on hand at all times to keep his place or tools
clean.
All equipment and bottles should be returned to the proper place after use.
Assume all chemicals used in the experiment are dangerous.
Eating or drinking in the laboratory is prohibited.
Do not pipette by mouth or carry reagents around the lab.
Wash your hands thoroughly before leaving the lab.
Take time to review the laboratory safety section and locate the following safety
equipment in the laboratory.
Safety Equipment Location
Fire Extinguishers
Fire Alarm
Eye Wash Fountains
Safety Shower
First Aid Box
Chemical Disposal
II
