Classification SJS
1. Syndrome steven Johnsons: <10% wide surface body
2. Sindron steven Johnson and NET ( Necrolysis Epidermal toxic) :
10- 30% body surface area
3. NET ( Necrolysis Epidermal toxic): >30% surface body
( Allanore , 2012)
Rules of nine
B. Pathophysiology
Pathophysiology from SJS alone still not yet is known,
however the main cause of SJS more than 50% is drug allergy.
suspected SJS allergy drug most common is analgesic /antipyretic
(45%), followed carbamazepine (20%), and Herb (13.3%). Cause
which other is amoxicillin , cotrimoxazole , dilantin , chloroquine,
ceftriaxone , and addictive (Anne, 2014).
Pathogenesis SJS/TEN not yet fully understood, however it is
believed that a specific agent (such as a drug or infection) will trigger
it an immune-mediated cytotoxic reaction against keratinocytes and
resulting in widespread apoptosis , i.e. detachment of epidermal cells
1. Syndrome steven Johnsons: <10% wide surface body
2. Sindron steven Johnson and NET ( Necrolysis Epidermal toxic) :
10- 30% body surface area
3. NET ( Necrolysis Epidermal toxic): >30% surface body
( Allanore , 2012)
Rules of nine
B. Pathophysiology
Pathophysiology from SJS alone still not yet is known,
however the main cause of SJS more than 50% is drug allergy.
suspected SJS allergy drug most common is analgesic /antipyretic
(45%), followed carbamazepine (20%), and Herb (13.3%). Cause
which other is amoxicillin , cotrimoxazole , dilantin , chloroquine,
ceftriaxone , and addictive (Anne, 2014).
Pathogenesis SJS/TEN not yet fully understood, however it is
believed that a specific agent (such as a drug or infection) will trigger
it an immune-mediated cytotoxic reaction against keratinocytes and
resulting in widespread apoptosis , i.e. detachment of epidermal cells
