Lecture 12: The Hoorn Studies summary -- HFT

12 .
The Hoorn Studies


There Are 4 types of clinical Research : -
Etiologic 9 occurrence of Disease

-
Diagnostic > predicts presence of Disease
-

Prognostic >predicts course of Disease
- Intervention 9 Defines medical Action .




For etiology research the Aim is to Assess the cause

of the Disease The RQ is made to Determine the
.




Association between Determinant & outcome .




The characteristics Are :

-
Explanatory Research
-
Demonstrate causality
- Determinant & Exposure occur before outcome
-

study Design = prospective effect

-
A
confounding variable is A variable that correlates
with both Dependent & independent variable It affects .




the variables being studied so that the results Do not

reflect the Relationship between them .




A
mediating variable is A variable that Links the

independent AND Dependent van .
, ans whose existence
explains the Relationship between the 2 variables .




In A Diagnostic Research ,the Aim is to Assess the presence or Absence of A

particular Disease The RQ is made to quantify
.




whether ants to what extent ☐ test contributes to

the Detection of those with the Disease .




The characteristics Are :
←
-
Study Design > cross-sectional
-
Descriptive research
- Determinants, gold standard & outcome are Assessed at

same time .