DIAGNOSIS OF ANAEMIA
Anaemia is a condition in which the number of RBCs
ortheir oxygen carrying capacity is insufficient to meet
physiological needs which by age sex altitude
vary
smoking or pregnancy status
Men 130 I
65g1L
Women I 20 I
Ssg 1L
Signs t symptoms of anaemia
Brain Light headed 1dizzy Fatigue weakness confusion
loss of consciousness
Lungs Short of breath TR R
Pallor
Cardiac Palpitations chest pain T H R
Causes Anaemia
of c
A
Failure of production
L Loss of RBC
B
Destruction of RBC
Production of sufficient numbers of functioning RBC
Synthesize ha em t synthesiseglobal chains with incorporated
Hbt Effective erythropoeisis t Functional bone marrow
,Hae m production A complex metabolic pathway which
results in the incorporation of an Fe 2T atom to form haem
I e tr Fe Haemoglobin
Iron metabolism d absorption e.g
dietryinsufficiency coeliac disease
RE system
Stores 500mg Liver 250mg CIT Ct
2mg1dg
T use due to T
TL absorption
erythropoiesis to Plasma transferrin
match demand e.g
4mg
Hbaienendoigntob.in
Bonemar YDailyjossclmg
2500mg erythroblasts 150mg Tissue
Fe
containing
Myoglobin 300mg enzymes 150mg
Iron is absorbed across the gastrointestinal epithelial cells
enhanced by vitc
Ha em iron animal non haemiron
Free intracellular iron is toxic to cells It is packagedby the
protein Ferritin Ferritin levels Iron Stores
Low Ferritin Iron deficiency
High Ferritin suggestive of normal In iron stores
, Ferritin is an acute phaseprotein so other things
many
can cause it to rise infection or inflammation so normal
Ferritin levels do not cross out Iron deficiency
Assessing the Iron profile
serum iron Significant variation during the dayand
in infection Cignore
Ferritin Increased with increasing iron acute phase
reactant Liver disease Down in deficiency
Transferrin Increased production in iron deficiency
measured
by determining Total Iron BindingCapacity
Transferrin saturation Measures the serum iron 1TIBC
reduced in iron deficiency
Failure to produce sufficient
Hb which provides the red
pigment to RBCs Cells are
Hypochromia pale low
H b content confirmed
by N
M CH and MCHC
Microcytic small low MCV
Always find the cause of the Iron
deficiency anaemia
Consider Die
try insufficiency vegan eating disorder
Anaemia is a condition in which the number of RBCs
ortheir oxygen carrying capacity is insufficient to meet
physiological needs which by age sex altitude
vary
smoking or pregnancy status
Men 130 I
65g1L
Women I 20 I
Ssg 1L
Signs t symptoms of anaemia
Brain Light headed 1dizzy Fatigue weakness confusion
loss of consciousness
Lungs Short of breath TR R
Pallor
Cardiac Palpitations chest pain T H R
Causes Anaemia
of c
A
Failure of production
L Loss of RBC
B
Destruction of RBC
Production of sufficient numbers of functioning RBC
Synthesize ha em t synthesiseglobal chains with incorporated
Hbt Effective erythropoeisis t Functional bone marrow
,Hae m production A complex metabolic pathway which
results in the incorporation of an Fe 2T atom to form haem
I e tr Fe Haemoglobin
Iron metabolism d absorption e.g
dietryinsufficiency coeliac disease
RE system
Stores 500mg Liver 250mg CIT Ct
2mg1dg
T use due to T
TL absorption
erythropoiesis to Plasma transferrin
match demand e.g
4mg
Hbaienendoigntob.in
Bonemar YDailyjossclmg
2500mg erythroblasts 150mg Tissue
Fe
containing
Myoglobin 300mg enzymes 150mg
Iron is absorbed across the gastrointestinal epithelial cells
enhanced by vitc
Ha em iron animal non haemiron
Free intracellular iron is toxic to cells It is packagedby the
protein Ferritin Ferritin levels Iron Stores
Low Ferritin Iron deficiency
High Ferritin suggestive of normal In iron stores
, Ferritin is an acute phaseprotein so other things
many
can cause it to rise infection or inflammation so normal
Ferritin levels do not cross out Iron deficiency
Assessing the Iron profile
serum iron Significant variation during the dayand
in infection Cignore
Ferritin Increased with increasing iron acute phase
reactant Liver disease Down in deficiency
Transferrin Increased production in iron deficiency
measured
by determining Total Iron BindingCapacity
Transferrin saturation Measures the serum iron 1TIBC
reduced in iron deficiency
Failure to produce sufficient
Hb which provides the red
pigment to RBCs Cells are
Hypochromia pale low
H b content confirmed
by N
M CH and MCHC
Microcytic small low MCV
Always find the cause of the Iron
deficiency anaemia
Consider Die
try insufficiency vegan eating disorder
