ANTI PLATELET
Haemostasis Arrest of haemorrhage
Thrombosis pathological formation of a haemostatic
plug within the vasculature in the ab cense of bleeding
Rudolph Virchow Triad
The three broad categories that contribute to thrombosis
Injury to vessel wall e
g ruptured atheromatous plaque
mainly arterial
Stasis of flow C due to immobility normally venous e.g
DUT
Abnormal coagulability due to disease medication
e.g Contraceptive pill
Rationale for anti platelet drugs
Critical role for platelets in formation of arterial thrombi
blood flows quicker at 4 pressure
Damaged endothelium activates platelets which respond
by adhering to endo and aggregating
Release of thromboxance AZ and ADP amplifies this process
Thrombin production via the coagulation cascade is also
accelerated with thrombus stabalised by conversion of fibrinogen
to fibrin
, Different drugs interfere with this process at diff points
Anti platelet agents
1 Cyclo
oxygenase inhibitors aspirin
2 A DP receptor pathway inhibitors clopidogrel
3 Phosphodiesterase inhibitors C Di pyrida mole
4 Glycoprotein 11 B1111 A membrane receptor antagonists
Antiplatelet d platelet aggregation and thrombus
formation in the arterial circulation because in faster
f vessels thrombi are composed mainly of platelets
towing
and fibrin
I
Haemostasis Arrest of haemorrhage
Thrombosis pathological formation of a haemostatic
plug within the vasculature in the ab cense of bleeding
Rudolph Virchow Triad
The three broad categories that contribute to thrombosis
Injury to vessel wall e
g ruptured atheromatous plaque
mainly arterial
Stasis of flow C due to immobility normally venous e.g
DUT
Abnormal coagulability due to disease medication
e.g Contraceptive pill
Rationale for anti platelet drugs
Critical role for platelets in formation of arterial thrombi
blood flows quicker at 4 pressure
Damaged endothelium activates platelets which respond
by adhering to endo and aggregating
Release of thromboxance AZ and ADP amplifies this process
Thrombin production via the coagulation cascade is also
accelerated with thrombus stabalised by conversion of fibrinogen
to fibrin
, Different drugs interfere with this process at diff points
Anti platelet agents
1 Cyclo
oxygenase inhibitors aspirin
2 A DP receptor pathway inhibitors clopidogrel
3 Phosphodiesterase inhibitors C Di pyrida mole
4 Glycoprotein 11 B1111 A membrane receptor antagonists
Antiplatelet d platelet aggregation and thrombus
formation in the arterial circulation because in faster
f vessels thrombi are composed mainly of platelets
towing
and fibrin
I
