BIOM 500 QUIZ 1 TEST 2020 SOLUTION WITH GRADED ANSWERS

BIOM 500 QUIZ 1 TEST 2020 SOLUTION WITH GRADED ANSWERSQuestion 1 In which of these conditions would you expect an elevation of p53 expression in normal cells? Selected Answer: All of these • Question 2 Which of these TSGs plays an important role in the direct inactivation of a GTP- 0 out of 2 points bound Ras oncogene and when it is mutated can result in sporadic sarcomas in affected patients? Selected Answer: [None Given] • Question 3 0 out of 2 points In a patient with a constitutively active receptor tyrosine kinase that increases the activity of PI3K, the administration of a drug that increases PTEN expression will likely inhibit tumorigenesis because; Selected Answer: PTEN competitively inhibits the catalytic subunit of PI3K • Question 4 2 out of 2 points You are evaluating a chemotherapeutic agent whose mode of action involves increasing Cytochrome C release from the mitochondria of treated cells - this drug most likely promotes the activity of this protein; Selected BA Answer: X • Question 5 0 out of 2 points In a patient with Essential thrombocytemia, a mutation in JAK2 - a downstream effector of cytokine receptor, results in a constitutive activation of the pseudokinase domain of the receptor and an inhibition of signaling via this pathway. Selected Answer: Tru e • Question 6 Which of these statements is not correct about Cytokine Receptor Signaling? 2 out of 2 points Selected Answer: They are the same as receptor tyrosine