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1. What characteristic BEST distinguishes rheumatoid arthritis (RA) from
osteoarthritis (OA)? - Correct Answer: Bilateral symmetric small-joint
involvement with morning stiffness > 1 hour
2. What pathophysiologic mechanism is MOST consistent with hip pain that
worsens after a long walk and improves after rest in OA? - Correct
Answer: Mechanical cartilage wear that increases with joint loading
3. What is the HALLMARK structural change in osteoarthritis pathophysiology?
- Correct Answer: Articular cartilage thinning, erosion, and osteophyte
formation
4. Where are Heberden nodes found in osteoarthritis? - Correct Answer:
Distal interphalangeal (DIP) joints
5. What laboratory result would be EXPECTED in a patient with osteoarthritis?
- Correct Answer: ESR and CRP within normal limits
6. What is the FIRST-line pharmacologic treatment for pain in osteoarthritis? -
Correct Answer: Acetaminophen (up to 3 g/day in older adults)
, 7. What non-pharmacologic intervention has the HIGHEST yield for symptom
relief in knee OA? - Correct Answer: Weight loss
8. In which hand should a cane be held by a patient with OA? - Correct
Answer: The opposite hand from the affected leg
9. What pathophysiologic process in rheumatoid arthritis leads to cartilage
and bone erosion? - Correct Answer: Pannus — hyperplastic synovial
tissue that invades and destroys cartilage
10.Which antibody is MORE specific for rheumatoid arthritis than rheumatoid
factor (RF)? - Correct Answer: Anti-cyclic citrullinated peptide (anti-CCP)
11.What extra-articular manifestation is MOST associated with rheumatoid
arthritis? - Correct Answer: Cardiovascular disease and pulmonary
involvement
12.What is the CRITICAL instruction for patient safety when prescribing
methotrexate for RA? - Correct Answer: Take methotrexate once a week
and take folic acid daily
13.What PRIORITY screening is needed before initiating a TNF inhibitor for RA?
- Correct Answer: Tuberculosis (TB) screening and Hepatitis B testing