T/F: a non-competitive allosteric agonist binds at the receptor active site to reduce
the efficacy of an agonist
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False
Which of the following four receptors can be directly phosphorylated upon drug
binding?
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Transmembrane receptors
, To eliminate a weakly basic drug, the kidney will ________ the urine allowing for pH
trapping of the drug in the tubules and prevent reabsorption.
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acidify
You administer a 100 mg tablet of drug X to a patient every 24 hours to achieve an
average steady-state plasma drug concentration of 10 mg/L. If you change the
dosage regimen to one 50 mg tablet every 12 hours, what will be the resulting
average plasma concentration (in mg/L) of the drug after 5 half lives?
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10
What is the volume of distribution? How much of this drug is distributed to the tissues
vs. remaining in the bloodstream?
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20 L; 3/4 of the drug is in the tissues
Drug X is a weak base with pKa of 8.4. In an environment with a pH of 1.4 (such as the
stomach), the ratio of ionized to non-ionized drug molecules (ionized: non- ionized)
in the will be:
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the efficacy of an agonist
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False
Which of the following four receptors can be directly phosphorylated upon drug
binding?
Give this one a try later!
Transmembrane receptors
, To eliminate a weakly basic drug, the kidney will ________ the urine allowing for pH
trapping of the drug in the tubules and prevent reabsorption.
Give this one a try later!
acidify
You administer a 100 mg tablet of drug X to a patient every 24 hours to achieve an
average steady-state plasma drug concentration of 10 mg/L. If you change the
dosage regimen to one 50 mg tablet every 12 hours, what will be the resulting
average plasma concentration (in mg/L) of the drug after 5 half lives?
Give this one a try later!
10
What is the volume of distribution? How much of this drug is distributed to the tissues
vs. remaining in the bloodstream?
Give this one a try later!
20 L; 3/4 of the drug is in the tissues
Drug X is a weak base with pKa of 8.4. In an environment with a pH of 1.4 (such as the
stomach), the ratio of ionized to non-ionized drug molecules (ionized: non- ionized)
in the will be:
Give this one a try later!
