ANCC Psychiatric-Mental Health Nurse
Practitioner Sample Questions and answers |
Updated New
What are the five factors that influence absorption? - answer- Gastric emptying
Time of contact with intestinal wall
Bowel perfusion
Food
Formation of non-absorbable complexes
Explain the hepatic first pass. - answer- Part of the drug is metabolized by the liver
before it reaches the blood.
Explain bioavailability. - answer- Percentage of administered drug that reaches systemic
circulation.
Name the 3 highly water-soluble drugs. - answer- Lithium, Amisulpride, Paliperidone
What are the 7 inhibitors of CYP? - answer- Paroxetine, Fluoxetine, Fluvoxamine,
Fluconazole, Ciprofloxacin, Ritonavir, Grapefruit juice
What are the 6 inducers of CYP? - answer- Carbamazepine, Phenytoin, Phenobarbital,
Primidone, smoking, St-John's Wort
What are the 6 factors that influence pharmacokinetics? - answer- Age, pregnancy,
obesity, sexe, comorbidities, genetics
Explain the half-life. - answer- The time it takes for the concentration of a drug to be
reduced by 50%
What are the 11 indications for TDM. - answer- Non-compliance/toxicity
Lack of efficacy/adverse effects at normal dose
Relapse in maintenance treatment
Change in drug formulation
Pregnancy
Age
Comorbidities
Drug interactions
Change in BMI
Finding the optimal drug concentration
Genetic polymorphisms
, What are the 4 factors influencing receptor binding? - answer- Affinity
Specificity
Saturability
Reversibility
Define intrinsic activity. - answer- The ability of a drug to initiate a response after binding
to a receptor
Define complete agonist vs. partial agonist. - answer- Decreased intrinsic activity,
decreased pharmacological effect, good affinity with receptor
Define competitive antagonist vs. non-competitive antagonist. - answer- Differences in
dose response curves
Increasing dose of agonist will change the response of a competitive antagonist.
What are the 4 targets of psychotropic drugs? - answer- Transporters, G-coupled
protein receptor, ion channels, enzymes
What is tachyphylaxis? - answer- Neurotransmitter depletion
What drugs are involved in induced psychotic disorders? - answer- Dopamine agonists
Chloroquine
Corticosteroids
Fluoroquinolones
Stimulants
What are the side effects of Cogentin? - answer- Dry mouth
Mydriasis
Blurred vision
Constipation
Urinary retention
Tachycardia
Delirium
Confusion
What is the effect of 5-HT2A receptor antagonist? - answer- Less EPS, improvement
negative symptoms, less hyperprolactinemia
What are the pharmacological treatments for tardive dyskinesia? - answer- Vitamin B6,
Gingko biloba, tetrabenazine, clonzepam
What antipsychotics increases the risk of akathisia? - answer- Latuda, Abilify
What antipsychotics increases the risk of EPS and hyperprolactinemia? - answer-
Risperidone, paliperidone
Practitioner Sample Questions and answers |
Updated New
What are the five factors that influence absorption? - answer- Gastric emptying
Time of contact with intestinal wall
Bowel perfusion
Food
Formation of non-absorbable complexes
Explain the hepatic first pass. - answer- Part of the drug is metabolized by the liver
before it reaches the blood.
Explain bioavailability. - answer- Percentage of administered drug that reaches systemic
circulation.
Name the 3 highly water-soluble drugs. - answer- Lithium, Amisulpride, Paliperidone
What are the 7 inhibitors of CYP? - answer- Paroxetine, Fluoxetine, Fluvoxamine,
Fluconazole, Ciprofloxacin, Ritonavir, Grapefruit juice
What are the 6 inducers of CYP? - answer- Carbamazepine, Phenytoin, Phenobarbital,
Primidone, smoking, St-John's Wort
What are the 6 factors that influence pharmacokinetics? - answer- Age, pregnancy,
obesity, sexe, comorbidities, genetics
Explain the half-life. - answer- The time it takes for the concentration of a drug to be
reduced by 50%
What are the 11 indications for TDM. - answer- Non-compliance/toxicity
Lack of efficacy/adverse effects at normal dose
Relapse in maintenance treatment
Change in drug formulation
Pregnancy
Age
Comorbidities
Drug interactions
Change in BMI
Finding the optimal drug concentration
Genetic polymorphisms
, What are the 4 factors influencing receptor binding? - answer- Affinity
Specificity
Saturability
Reversibility
Define intrinsic activity. - answer- The ability of a drug to initiate a response after binding
to a receptor
Define complete agonist vs. partial agonist. - answer- Decreased intrinsic activity,
decreased pharmacological effect, good affinity with receptor
Define competitive antagonist vs. non-competitive antagonist. - answer- Differences in
dose response curves
Increasing dose of agonist will change the response of a competitive antagonist.
What are the 4 targets of psychotropic drugs? - answer- Transporters, G-coupled
protein receptor, ion channels, enzymes
What is tachyphylaxis? - answer- Neurotransmitter depletion
What drugs are involved in induced psychotic disorders? - answer- Dopamine agonists
Chloroquine
Corticosteroids
Fluoroquinolones
Stimulants
What are the side effects of Cogentin? - answer- Dry mouth
Mydriasis
Blurred vision
Constipation
Urinary retention
Tachycardia
Delirium
Confusion
What is the effect of 5-HT2A receptor antagonist? - answer- Less EPS, improvement
negative symptoms, less hyperprolactinemia
What are the pharmacological treatments for tardive dyskinesia? - answer- Vitamin B6,
Gingko biloba, tetrabenazine, clonzepam
What antipsychotics increases the risk of akathisia? - answer- Latuda, Abilify
What antipsychotics increases the risk of EPS and hyperprolactinemia? - answer-
Risperidone, paliperidone
