BICH 409 EXAM 2 QUESTIONS WITH VERIFIED
ANSWERS
When a glutamic acid residue is shifted from the surface of a protein into a hydrophobic,
nonpolar pocket in the interior of the protein, the pka of the glutamic acid ___________.
A. Decreases
B. Increases
C. Remains unchanged - Answers - b. Increases
When a glutamic acid residue is brought into close proximity to an aspartate residue the
pka of the glutamic acid residue __________.
A. Decreases
B. Remains unchanged
C. Increases - Answers - c. Increases
If the ph decreases from 7.4 to 7.3, the p50 of hemoglobin would
A. Decrease
B. Cannot be determined
C. Increase
D. Remain unchanged
E. None of these - Answers - c. Increase
Which of the following statements about the oxidation state of iron is not true?
A. The iron center of the heme in Methemoglobin is in the Fe3+ state.
B. A water molecule binds to the heme bound iron when the iron is in the ferric state.
C. The binding of oxygen in hemoglobin or myoglobin, oxidizes the heme iron from the
Fe2+ to the Fe3+ state.
D. All of these statements are not true.
E. Oxygen binds to the heme bound iron when the iron is in the ferrous state. - Answers
- c. The binding of oxygen in hemoglobin or myoglobin, oxidizes the heme iron from the
Fe2+ to the Fe3+ state.
When the pco2 increases from 10 to 40 torr, the oxygen affinity of hemoglobin
__________.
A. Reamins unchanged
B. Increases
C. Decreases - Answers - c. Decreases
A monomeric oxygen-binding protein has a fractional saturation of 0.8 when po2 = 8
torr. What is the value of p50 for this protein and what is the value of the hill coefficient
n? - Answers - p50 = 2
N=1
ANSWERS
When a glutamic acid residue is shifted from the surface of a protein into a hydrophobic,
nonpolar pocket in the interior of the protein, the pka of the glutamic acid ___________.
A. Decreases
B. Increases
C. Remains unchanged - Answers - b. Increases
When a glutamic acid residue is brought into close proximity to an aspartate residue the
pka of the glutamic acid residue __________.
A. Decreases
B. Remains unchanged
C. Increases - Answers - c. Increases
If the ph decreases from 7.4 to 7.3, the p50 of hemoglobin would
A. Decrease
B. Cannot be determined
C. Increase
D. Remain unchanged
E. None of these - Answers - c. Increase
Which of the following statements about the oxidation state of iron is not true?
A. The iron center of the heme in Methemoglobin is in the Fe3+ state.
B. A water molecule binds to the heme bound iron when the iron is in the ferric state.
C. The binding of oxygen in hemoglobin or myoglobin, oxidizes the heme iron from the
Fe2+ to the Fe3+ state.
D. All of these statements are not true.
E. Oxygen binds to the heme bound iron when the iron is in the ferrous state. - Answers
- c. The binding of oxygen in hemoglobin or myoglobin, oxidizes the heme iron from the
Fe2+ to the Fe3+ state.
When the pco2 increases from 10 to 40 torr, the oxygen affinity of hemoglobin
__________.
A. Reamins unchanged
B. Increases
C. Decreases - Answers - c. Decreases
A monomeric oxygen-binding protein has a fractional saturation of 0.8 when po2 = 8
torr. What is the value of p50 for this protein and what is the value of the hill coefficient
n? - Answers - p50 = 2
N=1
