ATI RN Comprehensive Predictor 2026
– 300 Questions & Answers
Latest Update – Complete Study Guide – Graded A+
300 real exam-style questions · Full rationales · Why wrong explanations · 2026 updated
Abstract: This comprehensive ATI RN Comprehensive Predictor 2026 exam review contains 300
practice questions that mirror the actual ATI Comprehensive Predictor exam in content, difficulty,
and structure. Each question is paired with a verified correct answer, a detailed rationale, and a
"Why Wrong" breakdown for every incorrect option. Updated for the 2026 academic year, this
guide covers all core content areas tested on the exam, including management of care, safety
and infection control, health promotion and maintenance, psychosocial integrity,
pharmacological and parenteral therapies, reduction of risk potential, physiological adaptation,
medical-surgical nursing, maternal-newborn care, pediatrics, mental health nursing, and Next
Generation NCLEX (NGN) clinical judgment concepts. Designed for nursing students preparing
for the ATI Exit Exam, Comprehensive Predictor, and NCLEX-RN success.
Written by ATIExpertRN, DNP, RN – 15 years Nursing Educator
ATI RN Comprehensive Predictor: 100% | Verified: 2026 Academic Year
Section Questions Weight
Management of Care & Delegation 35 12%
Safety & Infection Control 30 10%
Health Promotion & Maintenance 25 8%
Psychosocial Integrity 30 10%
Pharmacological & Parenteral Therapies 40 13%
Reduction of Risk Potential 35 12%
Physiological Adaptation 45 15%
,Section Questions Weight
Medical-Surgical Nursing 60 20%
Content Overview
Management of Care & Delegation (35 Qs - 12%): Assignment and delegation, client advocacy, ethical and
legal principles, continuity of care, informed consent, advance directives, client rights, interdisciplinary
collaboration.
Safety & Infection Control (30 Qs - 10%): Standard, contact, droplet, airborne precautions; infection prevention;
isolation techniques; medical asepsis; surgical asepsis; falls prevention; safety devices; incident reporting.
Health Promotion & Maintenance (25 Qs - 8%): Growth and development across lifespan, immunizations,
screening, health screening, health education, nutrition, prenatal care, well-baby care, lifestyle modifications.
Psychosocial Integrity (30 Qs - 10%): Therapeutic communication, grief and loss, stress and coping, anxiety
disorders, depression, suicidal ideation, dementia, schizophrenia, substance abuse, family dynamics, cultural
competence.
Pharmacological & Parenteral Therapies (40 Qs - 13%): Medication administration, dosage calculation, adverse
effects, side effects, contraindications, drug interactions, high-alert medications, pain management, IV therapy,
blood transfusion.
Reduction of Risk Potential (35 Qs - 12%): Electrolyte imbalances, acid-base imbalances, ABG interpretation, risk
identification, diagnostic tests (labs, imaging), early warning signs, post-op complications, fall risk.
Physiological Adaptation (45 Qs - 15%): Cardiovascular, respiratory, neurological, renal, gastrointestinal,
endocrine, hematological, integumentary pathophysiology; shock; sepsis; wound healing; pressure injuries.
Medical-Surgical Nursing (60 Qs - 20%): Med-surg conditions (CHF, COPD, DM, MI, CVA, pneumonia, DVT, PE,
cirrhosis, pancreatitis, cancer), pre-op, intra-op, post-op care; NGN case studies; prioritization (ABCs).
Management of Care & Delegation (35 questions)
,Q1. A charge nurse is assigning clients on a medical-surgical unit. Which client should
be assigned to the RN rather than the LPN?
A A client post-op day 2 requiring a simple dressing change
B A client requiring a straight catheterization for a post-void residual
C A client with new-onset confusion and a blood pressure of 90/60
D A client receiving a continuous tube feeding
E A client with a colostomy requiring pouch change
Correct answer: C. A client with new-onset confusion and a blood pressure of 90/60
Rationale: New-onset confusion and hypotension indicate a potential change in condition
(e.g., sepsis, stroke). The RN must assess unstable clients. LPNs can perform stable,
predictable tasks like dressing changes, catheterizations, and tube feedings.
Why wrong:
A: Simple dressing changes on a stable post-op client can be delegated to an LPN.
B: Straight catheterization is a stable, predictable task for LPNs.
D: Continuous tube feeding on a stable client can be managed by an LPN.
E: Colostomy pouch changes are within LPN scope for stable clients.
Reference: ATI RN Comprehensive Predictor · Saunders NCLEX Review · Lewis's Medical-Surgical
Nursing.
, Q2. A charge nurse is assigning rooms for four clients. Which client should be placed in
a private room?
A Client with pneumonia
B Client with MRSA
C Client with a diabetic foot ulcer
D Client with COPD
E Client with urinary tract infection
Correct answer: B. Client with MRSA
Rationale: MRSA requires contact isolation. A private room is essential to prevent
transmission to other clients. While pneumonia may require droplet precautions, MRSA is
the priority for a single room assignment.
Why wrong:
A: Pneumonia requires droplet precautions, but a private room is not always required.
C: Diabetic foot ulcers require standard precautions.
D: COPD does not require isolation precautions.
E: UTI requires standard precautions.
Reference: ATI RN Comprehensive Predictor · Saunders NCLEX Review · Lewis's Medical-Surgical
Nursing.
– 300 Questions & Answers
Latest Update – Complete Study Guide – Graded A+
300 real exam-style questions · Full rationales · Why wrong explanations · 2026 updated
Abstract: This comprehensive ATI RN Comprehensive Predictor 2026 exam review contains 300
practice questions that mirror the actual ATI Comprehensive Predictor exam in content, difficulty,
and structure. Each question is paired with a verified correct answer, a detailed rationale, and a
"Why Wrong" breakdown for every incorrect option. Updated for the 2026 academic year, this
guide covers all core content areas tested on the exam, including management of care, safety
and infection control, health promotion and maintenance, psychosocial integrity,
pharmacological and parenteral therapies, reduction of risk potential, physiological adaptation,
medical-surgical nursing, maternal-newborn care, pediatrics, mental health nursing, and Next
Generation NCLEX (NGN) clinical judgment concepts. Designed for nursing students preparing
for the ATI Exit Exam, Comprehensive Predictor, and NCLEX-RN success.
Written by ATIExpertRN, DNP, RN – 15 years Nursing Educator
ATI RN Comprehensive Predictor: 100% | Verified: 2026 Academic Year
Section Questions Weight
Management of Care & Delegation 35 12%
Safety & Infection Control 30 10%
Health Promotion & Maintenance 25 8%
Psychosocial Integrity 30 10%
Pharmacological & Parenteral Therapies 40 13%
Reduction of Risk Potential 35 12%
Physiological Adaptation 45 15%
,Section Questions Weight
Medical-Surgical Nursing 60 20%
Content Overview
Management of Care & Delegation (35 Qs - 12%): Assignment and delegation, client advocacy, ethical and
legal principles, continuity of care, informed consent, advance directives, client rights, interdisciplinary
collaboration.
Safety & Infection Control (30 Qs - 10%): Standard, contact, droplet, airborne precautions; infection prevention;
isolation techniques; medical asepsis; surgical asepsis; falls prevention; safety devices; incident reporting.
Health Promotion & Maintenance (25 Qs - 8%): Growth and development across lifespan, immunizations,
screening, health screening, health education, nutrition, prenatal care, well-baby care, lifestyle modifications.
Psychosocial Integrity (30 Qs - 10%): Therapeutic communication, grief and loss, stress and coping, anxiety
disorders, depression, suicidal ideation, dementia, schizophrenia, substance abuse, family dynamics, cultural
competence.
Pharmacological & Parenteral Therapies (40 Qs - 13%): Medication administration, dosage calculation, adverse
effects, side effects, contraindications, drug interactions, high-alert medications, pain management, IV therapy,
blood transfusion.
Reduction of Risk Potential (35 Qs - 12%): Electrolyte imbalances, acid-base imbalances, ABG interpretation, risk
identification, diagnostic tests (labs, imaging), early warning signs, post-op complications, fall risk.
Physiological Adaptation (45 Qs - 15%): Cardiovascular, respiratory, neurological, renal, gastrointestinal,
endocrine, hematological, integumentary pathophysiology; shock; sepsis; wound healing; pressure injuries.
Medical-Surgical Nursing (60 Qs - 20%): Med-surg conditions (CHF, COPD, DM, MI, CVA, pneumonia, DVT, PE,
cirrhosis, pancreatitis, cancer), pre-op, intra-op, post-op care; NGN case studies; prioritization (ABCs).
Management of Care & Delegation (35 questions)
,Q1. A charge nurse is assigning clients on a medical-surgical unit. Which client should
be assigned to the RN rather than the LPN?
A A client post-op day 2 requiring a simple dressing change
B A client requiring a straight catheterization for a post-void residual
C A client with new-onset confusion and a blood pressure of 90/60
D A client receiving a continuous tube feeding
E A client with a colostomy requiring pouch change
Correct answer: C. A client with new-onset confusion and a blood pressure of 90/60
Rationale: New-onset confusion and hypotension indicate a potential change in condition
(e.g., sepsis, stroke). The RN must assess unstable clients. LPNs can perform stable,
predictable tasks like dressing changes, catheterizations, and tube feedings.
Why wrong:
A: Simple dressing changes on a stable post-op client can be delegated to an LPN.
B: Straight catheterization is a stable, predictable task for LPNs.
D: Continuous tube feeding on a stable client can be managed by an LPN.
E: Colostomy pouch changes are within LPN scope for stable clients.
Reference: ATI RN Comprehensive Predictor · Saunders NCLEX Review · Lewis's Medical-Surgical
Nursing.
, Q2. A charge nurse is assigning rooms for four clients. Which client should be placed in
a private room?
A Client with pneumonia
B Client with MRSA
C Client with a diabetic foot ulcer
D Client with COPD
E Client with urinary tract infection
Correct answer: B. Client with MRSA
Rationale: MRSA requires contact isolation. A private room is essential to prevent
transmission to other clients. While pneumonia may require droplet precautions, MRSA is
the priority for a single room assignment.
Why wrong:
A: Pneumonia requires droplet precautions, but a private room is not always required.
C: Diabetic foot ulcers require standard precautions.
D: COPD does not require isolation precautions.
E: UTI requires standard precautions.
Reference: ATI RN Comprehensive Predictor · Saunders NCLEX Review · Lewis's Medical-Surgical
Nursing.
