Differential Diagnosis Official Practice Exam
Actual Exam 2026/2027 with Detailed Rationales |
Complete Exam-Style Questions | Pass
Guaranteed – A+ Graded
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SECTION 1: FOUNDATIONS, GENERAL ASSESSMENT & MENTAL STATUS Q1 – Q10
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Question 1 of 50
72-year-old man is brought to the clinic by his daughter, who reports he has been increasingly
A
forgetful over the past three months. The patient insists he is fine and provides vague answers
to questions about his medication adherence. Recognizing the potential for unreliable
self-reporting, the most appropriate next step in the history-taking process is to:
. Interview the daughter separately to obtain a collateral history. ✓ CORRECT
A
B. Administer the Montreal Cognitive Assessment before proceeding.
C. Confront the patient about his memory lapses to establish accuracy.
D. Rely solely on the pharmacy refill records to determine adherence.
orrect Answer: A
C
Rationale: Interviewing the daughter separately provides a collateral history that is essential
when a patient's insight or reliability is compromised by cognitive decline. Administering the
MoCA is a necessary diagnostic step, but it cannot replace the critical need for an accurate
historical timeline and baseline function from a reliable informant. Always corroborate historical
data with a secondary source when the patient's mental status is in question.
Question 2 of 50
68-year-old woman presents with concerns about her memory, stating she frequently
A
misplaces her keys and forgets names. Her daughter reports no significant functional
impairment in daily activities. To objectively screen for mild cognitive impairment in this
time-limited visit, the most appropriate initial assessment tool is the:
. Geriatric Depression Scale.
A
B. Mini-Cog examination. ✓ CORRECT
C. Full Mini-Mental State Examination.
,D. Clinical Dementia Rating Scale.
orrect Answer: B
C
Rationale: The Mini-Cog combines three-word recall and a clock-drawing test, providing a rapid,
validated screening tool for mild cognitive impairment that is unaffected by language or
education level. The full MMSE takes longer to administer and is more sensitive to education
level, making it less ideal for a quick initial screen. The Mini-Cog is the preferred rapid screening
tool in busy primary care settings.
Question 3 of 50
55-year-old man presents with a 15-pound unintentional weight loss over two months.
A
Physical examination reveals temporal wasting and decreased muscle mass. To best assess for
protein-energy malnutrition in this patient, the advanced practice nurse should evaluate for:
. Peripheral edema.
A
B. Temporalis muscle wasting. ✓ CORRECT
C. Hair follicle changes.
D. Skin turgor elasticity.
orrect Answer: B
C
Rationale: Temporalis muscle wasting is a hallmark clinical indicator of protein-energy
malnutrition, reflecting significant loss of lean body mass. Peripheral edema is often associated
with malnutrition due to low albumin, but it is a late and non-specific finding that can also be
caused by heart or kidney failure. Assessing for temporal wasting provides a direct, rapid visual
clue to severe protein depletion.
Question 4 of 50
45-year-old man who speaks only Mandarin presents with acute abdominal pain and appears
A
distressed. The clinic does not have a Mandarin-speaking interpreter available. To accurately
assess the severity and characteristics of the patient's pain, the most appropriate assessment
strategy is to utilize the:
. Numeric Rating Scale.
A
B. Wong-Baker FACES scale. ✓ CORRECT
C. Verbal Descriptor Scale.
D. McGill Pain Questionnaire.
orrect Answer: B
C
Rationale: The Wong-Baker FACES scale relies on visual representations of pain rather than
language proficiency, making it the most effective tool for cross-cultural pain assessment when
a language barrier exists. The Verbal Descriptor Scale and Numeric Rating Scale require
, translation or shared language understanding to be accurately utilized. Visual pain scales bridge
the communication gap when linguistic barriers prevent standard subjective pain reporting.
Question 5 of 50
30-year-old female marathon runner presents for a routine physical. Her resting heart rate is
A
48 bpm, and her blood pressure is 108/70 mmHg. She denies any dizziness, syncope, or chest
pain. The advanced practice nurse interprets these vital signs as:
. Normal physiological adaptation to aerobic conditioning. ✓ CORRECT
A
B. Sinus bradycardia requiring an electrocardiogram.
C. Hypovolemia secondary to excessive diaphoresis.
D. Occult cardiac conduction system disease.
orrect Answer: A
C
Rationale: Resting bradycardia and a lower baseline blood pressure are normal physiological
adaptations in highly trained athletes due to increased stroke volume and vagal tone. Ordering
an immediate ECG would be indicated only if the patient exhibited symptoms of hypoperfusion
such as syncope or dizziness. Always correlate vital sign abnormalities with the patient's clinical
context and symptomatology before over-investigating.
Question 6 of 50
n 80-year-old woman is admitted to the hospital for a urinary tract infection. On day two, the
A
nurse notes the patient is acutely confused, fluctuating between hyperactivity and lethargy, and
is unable to focus on the interview. The most accurate clinical assessment of this change in
mental status is:
. Progression of underlying Alzheimer dementia.
A
B. Acute onset of delirium. ✓ CORRECT
C. Exacerbation of vascular dementia.
D. Depression presenting as pseudodementia.
orrect Answer: B
C
Rationale: Delirium is characterized by an acute onset, fluctuating course, and inattention, often
triggered by an underlying medical condition like a urinary tract infection. Dementia, such as
Alzheimer or vascular types, typically presents with a chronic, insidious progression of cognitive
decline without the acute fluctuation seen here. The acute, fluctuating nature of the confusion is
the hallmark diagnostic feature that distinguishes delirium from dementia.
Question 7 of 50