Pathophysiology: ARDS
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1. Acute respiratory distress syn- Acute condition characterized by bilateral pulmonary infiltrates
drome (ARDS) & severe hypoxemia that is non-cardiogenic pulmonary edema
within hours to days of inciting event
2. What severity of hypoxemia is Defined as ratio of PaO2 (partial pressure of oxygen in arterial
necessary to make diagnosis blood) to fraction of oxygen in inspired air (FiO2)
of ARDS?
3. Identify the three categoriza- Mild (PaO2/FiO2=200-300), Moderate (PaO2/FiO2=
tions of ARDS 100-200) and Severe (PaO2/FiO2< 100)
4. What is ARDS associated with? Diffuse alveolar damage (DAD) and lung capillary endothelial
injury
5. Identify the two components Microvascular endothelium & epithelial lining of alveoli
that make up the alveolar-cap-
illary barrier
6. Damage of ___ and ___ from Vascular endothelium (indirect) and Alveolar epithelium (di-
insults ultimately (trauma) can rect)
lead to ARDS?
7. Indirect cases of ARDS Site of injury apart from alveoli (i.e vasculature)
8. Direct cases of ARDS Injury to alveolar epithelium
9. Etiologies of vascular endothe- -Sepsis
lium injury
10. Etiologies of alveolar epitheli- Aspiration (i.e stomach acid) or inhalation (i.e smoke, water)
um injury injury
11. Identify the two types of alveo- Type I and Type II
lar epithelial cells
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