Antimicrobi
als
▪Differentiate Bacteriostatic and Bacterialcidal.
•bactericidal – directly lethal to bacteria at clinically achievable concentrations
•bacteriostatic – slow bacterial growth but do not cause cell death
▪What is the difference between broad spectrum and narrow spectrum?
•Narrow – active against only a few species of microorganisms
•Broad – active against a wide variety of microbes
▪Which is preferred?
•Narrow-spectrum
▪antibiotic classifications by MOA?
•Drugs that inhibit bacterial cell wall synthesis
oPenicillins, cephalosporins
•Drugs that increase cell membrane permeability
oAmphotericin B
•Drugs that cause lethal inhibition of bacterial protein synthesis
oAminoglycosides
•Drugs that cause nonlethal inhibition of protein synthesis
oTetracyclines
•Drugs that inhibit bacterial synthesis of DNA and RNA
oRifampin, metronidazole, ciprofloxacin
•Antimetabolites
oTrimethoprim, sulfonamides
•Drugs that suppress viral replication
▪antibiotic classifications by organism?
•Narrow Spectrum
oGram positive cocci and gram positive bacilli
➢Penicillin
➢Vancomycin
➢Erythromycin
➢clindamycin
oGram negative aerobes
➢Aminoglycosides – gentamicin
➢cephalosporins
oTB
➢Isoniazid
➢Rifampin
➢Ethambutol
➢pyrazinamide
•Broad Spectrum
oGram positive cocci and gram negative bacilli
➢Ampicillin
➢Piperacillin Antimicrobi
als ➢Tetracyclines
als
▪Differentiate Bacteriostatic and Bacterialcidal.
•bactericidal – directly lethal to bacteria at clinically achievable concentrations
•bacteriostatic – slow bacterial growth but do not cause cell death
▪What is the difference between broad spectrum and narrow spectrum?
•Narrow – active against only a few species of microorganisms
•Broad – active against a wide variety of microbes
▪Which is preferred?
•Narrow-spectrum
▪antibiotic classifications by MOA?
•Drugs that inhibit bacterial cell wall synthesis
oPenicillins, cephalosporins
•Drugs that increase cell membrane permeability
oAmphotericin B
•Drugs that cause lethal inhibition of bacterial protein synthesis
oAminoglycosides
•Drugs that cause nonlethal inhibition of protein synthesis
oTetracyclines
•Drugs that inhibit bacterial synthesis of DNA and RNA
oRifampin, metronidazole, ciprofloxacin
•Antimetabolites
oTrimethoprim, sulfonamides
•Drugs that suppress viral replication
▪antibiotic classifications by organism?
•Narrow Spectrum
oGram positive cocci and gram positive bacilli
➢Penicillin
➢Vancomycin
➢Erythromycin
➢clindamycin
oGram negative aerobes
➢Aminoglycosides – gentamicin
➢cephalosporins
oTB
➢Isoniazid
➢Rifampin
➢Ethambutol
➢pyrazinamide
•Broad Spectrum
oGram positive cocci and gram negative bacilli
➢Ampicillin
➢Piperacillin Antimicrobi
als ➢Tetracyclines
