Science Biology Molecular Biology
BIOL252
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Genetic Variation definitions BIOL252 Muscles Gene expression Speciat
31 terms 98 terms 42 terms 96 terms
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The ER sends proteins and lipids to the Golgi for modification and sorting.
Choose an answer
1 Mitochondrial interaction with The nucleus 2 ER interaction with Golgi apparatus
3 Lysosome interaction with phagosomes 4 Ribosome interaction with mRNA
Don't know?
Terms in this set (94) Hide definitions
How do proteins enter the rough ER? Proteins are imported into the rough ER during their synthesis. This is a co-
translational process where the ribosome synthesizes the polypeptide while the
protein is simultaneously imported into the ER.
What is the signal sequence in protein synthesis? A short amino acid sequence that directs the protein into the ER.
, What types of proteins are synthesized in the ER? transmembrane proteins (e.g., receptors) and secreted proteins (e.g., hormones,
enzymes, blood proteins).
What is the role of signal-recognition particle (SRP) in Binds to the signal peptide on the new peptide chain, pauses translation then
protein synthesis? directs the ribosome to the SRP receptor on the ER membrane
What happens once the SRP-ribosome complex binds to Once the SRP-ribosome complex binds to the SRP receptor, translation resumes,
the ER membrane? and the growing polypeptide enters the Sec61 translocon channel into the ER.
What is the function of the SEC61 complex? The SEC61 complex is a protein channel through which the nascent polypeptide
chain passes to enter the ER lumen or integrate into the membrane.
How does the signal peptide affect translation during The signal peptide halts translation temporarily (via the SRP) and directs the
protein synthesis in the ER? ribosome to the ER for co-translational translocation.
What happens when a signal peptide is recognized by The SRP halts translation, binds to the ribosome, and directs the ribosome to the
the SRP? SRP receptor on the ER membrane to continue protein synthesis in the ER.
How does the SEC61 complex contribute to protein The SEC61 complex opens to allow the polypeptide chain to pass through the ER
translocation? membrane, where it either enters the lumen or becomes embedded in the
membrane.
What are 'start-transfer' and 'stop-transfer' sequences in Start-transfer sequences initiate the translocation of proteins into the ER, while
protein synthesis? stop-transfer sequences halt it and anchor the protein in the membrane.
What occurs when a stop-transfer sequence is The translocation channel is separated from the peptide, and translation continues
encountered? in the cytoplasm, completing the intracellular domain of the protein.
What is the significance of hydrophobic regions in Hydrophobic regions in multipass transmembrane proteins interact with the ER
multipass transmembrane proteins? membrane, allowing multiple start-transfer and stop-transfer sequences to anchor
the protein in the membrane.
BIOL252
Leave the first rating
Students also studied
Flashcard sets Study guides
Genetic Variation definitions BIOL252 Muscles Gene expression Speciat
31 terms 98 terms 42 terms 96 terms
Alyssa_Patel21 Preview lmyang Preview Alyssa_Patel21 Preview Aly
Practice questions for this set
Learn 1 /7 Study with Learn
The ER sends proteins and lipids to the Golgi for modification and sorting.
Choose an answer
1 Mitochondrial interaction with The nucleus 2 ER interaction with Golgi apparatus
3 Lysosome interaction with phagosomes 4 Ribosome interaction with mRNA
Don't know?
Terms in this set (94) Hide definitions
How do proteins enter the rough ER? Proteins are imported into the rough ER during their synthesis. This is a co-
translational process where the ribosome synthesizes the polypeptide while the
protein is simultaneously imported into the ER.
What is the signal sequence in protein synthesis? A short amino acid sequence that directs the protein into the ER.
, What types of proteins are synthesized in the ER? transmembrane proteins (e.g., receptors) and secreted proteins (e.g., hormones,
enzymes, blood proteins).
What is the role of signal-recognition particle (SRP) in Binds to the signal peptide on the new peptide chain, pauses translation then
protein synthesis? directs the ribosome to the SRP receptor on the ER membrane
What happens once the SRP-ribosome complex binds to Once the SRP-ribosome complex binds to the SRP receptor, translation resumes,
the ER membrane? and the growing polypeptide enters the Sec61 translocon channel into the ER.
What is the function of the SEC61 complex? The SEC61 complex is a protein channel through which the nascent polypeptide
chain passes to enter the ER lumen or integrate into the membrane.
How does the signal peptide affect translation during The signal peptide halts translation temporarily (via the SRP) and directs the
protein synthesis in the ER? ribosome to the ER for co-translational translocation.
What happens when a signal peptide is recognized by The SRP halts translation, binds to the ribosome, and directs the ribosome to the
the SRP? SRP receptor on the ER membrane to continue protein synthesis in the ER.
How does the SEC61 complex contribute to protein The SEC61 complex opens to allow the polypeptide chain to pass through the ER
translocation? membrane, where it either enters the lumen or becomes embedded in the
membrane.
What are 'start-transfer' and 'stop-transfer' sequences in Start-transfer sequences initiate the translocation of proteins into the ER, while
protein synthesis? stop-transfer sequences halt it and anchor the protein in the membrane.
What occurs when a stop-transfer sequence is The translocation channel is separated from the peptide, and translation continues
encountered? in the cytoplasm, completing the intracellular domain of the protein.
What is the significance of hydrophobic regions in Hydrophobic regions in multipass transmembrane proteins interact with the ER
multipass transmembrane proteins? membrane, allowing multiple start-transfer and stop-transfer sequences to anchor
the protein in the membrane.
