, Exam Overview
Feature Details
Course NSG 5240 Advanced Pharmacology
Institution South College (Graduate Nursing – NP, CNS, Nurse Educator
programs)
Format Multiple Choice
Total 200
Questions
Key Pharmacokinetics/Pharmacodynamics, Autonomic Pharmacology,
Domains Cardiovascular, Endocrine, CNS/Psych, Infectious Disease,
Special Populations
SECTION 1: PHARMACOKINETICS & PHARMACODYNAMICS (Questions 1-40)
1. The U.S. Food and Drug Administration (FDA) regulates which of the following?
A) Prescribing practices of nurse practitioners
B) The official labeling for all prescription and over-the-counter drugs
C) State-level licensing requirements
D) Controlled substance scheduling
Answer: B. The FDA is responsible for ensuring the safety, efficacy, and security of drugs,
biological products, and medical devices, including approving and regulating official labeling
for all prescription and OTC medications.
2. Nurse practitioner prescriptive authority is ultimately regulated by:
A) The National Council of State Boards of Nursing (NCSBN)
, B) The State Board of Nursing for each state
C) The U.S. Drug Enforcement Administration (DEA)
D) The State Board of Pharmacy
Answer: B. Prescriptive authority for nurse practitioners is regulated by individual state
boards of nursing.
3. A patient with liver cirrhosis has reduced metabolism of a drug that normally
undergoes extensive first-pass effect. How will this affect the oral dose of the drug?
A) Increased first-pass metabolism
B) Decreased bioavailability
C) Significantly increased bioavailability
D) No change in drug levels
Answer: C. First-pass metabolism occurs in the liver. If liver function is impaired, less drug
is metabolized before reaching systemic circulation, leading to higher bioavailability and risk
of toxicity.
4. A drug has a half-life of 12 hours. Approximately how many hours will it take to
reach steady state?
A) 24 hours
B) 36 hours
C) 48 hours
D) 60 hours
Answer: D. Steady state is achieved after approximately 4-5 half-lives. 5 × 12 hours = 60
hours.
, 5. Which route of administration bypasses the first-pass effect?
A) Oral
B) Sublingual
C) Rectal
D) Both B and C
Answer: D. Sublingual and rectal routes allow drug absorption directly into systemic
circulation, avoiding portal circulation and hepatic first-pass metabolism.
6. An agonist drug is best defined as a substance that:
A) Binds to a receptor and blocks its action
B) Binds to a receptor and activates it, producing a maximal response
C) Binds to a receptor and produces a partial response
D) Inactivates enzymes
Answer: B. A full agonist binds to and activates a receptor, producing the maximal tissue
response.
7. Which transporter is responsible for renal secretion of many organic anions and
can be a site of drug interactions?
A) P-glycoprotein
B) OAT (organic anion transporter)
C) OCT (organic cation transporter)
D) BCRP
Answer: B. OATs mediate renal secretion of drugs like penicillin and methotrexate.
Probenecid inhibits OAT, increasing their levels.
Feature Details
Course NSG 5240 Advanced Pharmacology
Institution South College (Graduate Nursing – NP, CNS, Nurse Educator
programs)
Format Multiple Choice
Total 200
Questions
Key Pharmacokinetics/Pharmacodynamics, Autonomic Pharmacology,
Domains Cardiovascular, Endocrine, CNS/Psych, Infectious Disease,
Special Populations
SECTION 1: PHARMACOKINETICS & PHARMACODYNAMICS (Questions 1-40)
1. The U.S. Food and Drug Administration (FDA) regulates which of the following?
A) Prescribing practices of nurse practitioners
B) The official labeling for all prescription and over-the-counter drugs
C) State-level licensing requirements
D) Controlled substance scheduling
Answer: B. The FDA is responsible for ensuring the safety, efficacy, and security of drugs,
biological products, and medical devices, including approving and regulating official labeling
for all prescription and OTC medications.
2. Nurse practitioner prescriptive authority is ultimately regulated by:
A) The National Council of State Boards of Nursing (NCSBN)
, B) The State Board of Nursing for each state
C) The U.S. Drug Enforcement Administration (DEA)
D) The State Board of Pharmacy
Answer: B. Prescriptive authority for nurse practitioners is regulated by individual state
boards of nursing.
3. A patient with liver cirrhosis has reduced metabolism of a drug that normally
undergoes extensive first-pass effect. How will this affect the oral dose of the drug?
A) Increased first-pass metabolism
B) Decreased bioavailability
C) Significantly increased bioavailability
D) No change in drug levels
Answer: C. First-pass metabolism occurs in the liver. If liver function is impaired, less drug
is metabolized before reaching systemic circulation, leading to higher bioavailability and risk
of toxicity.
4. A drug has a half-life of 12 hours. Approximately how many hours will it take to
reach steady state?
A) 24 hours
B) 36 hours
C) 48 hours
D) 60 hours
Answer: D. Steady state is achieved after approximately 4-5 half-lives. 5 × 12 hours = 60
hours.
, 5. Which route of administration bypasses the first-pass effect?
A) Oral
B) Sublingual
C) Rectal
D) Both B and C
Answer: D. Sublingual and rectal routes allow drug absorption directly into systemic
circulation, avoiding portal circulation and hepatic first-pass metabolism.
6. An agonist drug is best defined as a substance that:
A) Binds to a receptor and blocks its action
B) Binds to a receptor and activates it, producing a maximal response
C) Binds to a receptor and produces a partial response
D) Inactivates enzymes
Answer: B. A full agonist binds to and activates a receptor, producing the maximal tissue
response.
7. Which transporter is responsible for renal secretion of many organic anions and
can be a site of drug interactions?
A) P-glycoprotein
B) OAT (organic anion transporter)
C) OCT (organic cation transporter)
D) BCRP
Answer: B. OATs mediate renal secretion of drugs like penicillin and methotrexate.
Probenecid inhibits OAT, increasing their levels.
