Answers 2026 Updated.
Most common coagulation disorder - Answer thrombocytopenia
THERAPUTIC aPTT - Answer 60-80
MOA of anticoagulants - Answer Lengthen clotting time and prevent thrombi from forming or
growing larger
They do NOT dissolve clots: prevent growing
Onset for IV heprian - Answer Immediate
Onset for SQ heprian - Answer About an hour
AE heprian - Answer Abnormal bleeding,
possible allergies (animal products), osteoporosis!!!!
caution with renal or hepatic failure
HIT!!!!
HIT - Answer Heparin-induced thrombocytopenia occurs in up to 5% of patients; markedly
INCREASES platelet aggregation and thrombolytic events
CI for heprian - Answer Internal bleeding,
intracranial hemorrhage,
severe HTN,
bacterial endocarditis!!!!
, severe thrombocytopenia
BBW for heprian - Answer Epidural or spinal hematomas may occur in clients with epidural or
lumbar puncture
Onset of protamine sulfate - Answer 5 minutes
DI for heprian - Answer nicotine,
, digoxin,
tetracycline,
antihistamines.
Ginger,
garlic,
green tea,
and gingko.
Pregnancy and heprian - Answer Does not cross placental barrier and is not secreted in
breast milk; anticoagulant of choice for pregnancy and lactation. Caution during the peripartum
period.
Difference between lovenox and heprian - Answer Unable to bind thrombin; More selective
for Factor Xa inhibition
Advantages of Enoxaparin (Lovenox) - Answer More predictable response; dose determined
based on weight!!!
Less frequent monitoring
Half-life is 2-4 times longer than heparin
Once daily dosing, SQ
Why is lovenox typically dosed for 1400 - Answer Gives dr time to adjust order based off of
labs before nurse gives it
Disadvantage of Enoxaprin (Lovenox) - Answer More expensive
MOA of antiplatelets - Answer Antiplatelet agents provide anticoagulation by reducing the
aggregation properties of platelets
3 subtypes of antiplatelets - Answer Aspirin
Adenosine diphosphate (ADP) receptor blockers
Prototype: Clopidogrel (Plavix)
Glycoprotein IIb/IIIa receptor blockers
Prototype: Abciximab (ReoPro)