CHM 451 EXAM 1_110 QUESTIONS WITH
VERIFIED ANSWERS
What drug does to the body
MOA
Determine drug classification - CORRECT ANSWER Pharmacodynamics
State legislatures through licensing boards - CORRECT ANSWER Primary
Organizations That Control Privilege of Prescribing Drugs
Pass exams
Pay fees
Education requirements - CORRECT ANSWER Criteria Required For Privilege of
Prescribing
What body does to the drug
ADME - CORRECT ANSWER Pharmacokinetics
Different responses to drug based on genetic background - CORRECT ANSWER
Pharmacogenetics
Genetic techniques to find new drug - CORRECT ANSWER Pharmacogenomics
1) Program selection
,2) ID and validation of drug target
3) Assay
4) ID lead compound
5) Lead optimization
6) ID drug candidate
7) Clinical trials
8) Release drug
9) Follow-up monitoring
10) $$$ - CORRECT ANSWER Steps of Modern Drug Research
Things to consider:
medical need
current therapy available
competitor activity
commercial opportunity - CORRECT ANSWER Program Selection
Drug targets:
G-proteins (45%)
enzymes (28%)
hormones (11%)
ion channels (5%)
nuclear receptors (2%)
, Drug target must be critical to disease process - CORRECT ANSWER ID and
Validation of Drug Target
Check if compound biologically active
Hits -> compound active in assay
Leads -> compound active in animal model - CORRECT ANSWER Assay
Determine synthetic routes for SAR and optimize molecular structure for drug
activity
Where compound comes from:
natural products (plants/bacteria/animals - 61%)
rational drug design (21%)
biological peptides (14%)
vaccines (4%) - CORRECT ANSWER Lead Optimization
Phase I:
30-100 healthy volunteers
determine drug safety
Phase II:
100-300 diseased people
single-blind study
VERIFIED ANSWERS
What drug does to the body
MOA
Determine drug classification - CORRECT ANSWER Pharmacodynamics
State legislatures through licensing boards - CORRECT ANSWER Primary
Organizations That Control Privilege of Prescribing Drugs
Pass exams
Pay fees
Education requirements - CORRECT ANSWER Criteria Required For Privilege of
Prescribing
What body does to the drug
ADME - CORRECT ANSWER Pharmacokinetics
Different responses to drug based on genetic background - CORRECT ANSWER
Pharmacogenetics
Genetic techniques to find new drug - CORRECT ANSWER Pharmacogenomics
1) Program selection
,2) ID and validation of drug target
3) Assay
4) ID lead compound
5) Lead optimization
6) ID drug candidate
7) Clinical trials
8) Release drug
9) Follow-up monitoring
10) $$$ - CORRECT ANSWER Steps of Modern Drug Research
Things to consider:
medical need
current therapy available
competitor activity
commercial opportunity - CORRECT ANSWER Program Selection
Drug targets:
G-proteins (45%)
enzymes (28%)
hormones (11%)
ion channels (5%)
nuclear receptors (2%)
, Drug target must be critical to disease process - CORRECT ANSWER ID and
Validation of Drug Target
Check if compound biologically active
Hits -> compound active in assay
Leads -> compound active in animal model - CORRECT ANSWER Assay
Determine synthetic routes for SAR and optimize molecular structure for drug
activity
Where compound comes from:
natural products (plants/bacteria/animals - 61%)
rational drug design (21%)
biological peptides (14%)
vaccines (4%) - CORRECT ANSWER Lead Optimization
Phase I:
30-100 healthy volunteers
determine drug safety
Phase II:
100-300 diseased people
single-blind study
